GENETIC TYPE AND THE ENDOCRINES 



703 



was simply a precautionary measure carried out until the 

 transplant should "take." 



The behavior tests were resumed 15 days after the opera- 

 tion. The C-R was noted to be much weaker than in the normal 

 period, and signs of parathyroid deficiency became apparent 

 at about this time. For 2 days marked anorexia and vomiting, 

 accompanied by coarse twitching of the temporal muscles and 

 by disturbances of locomotion, were noted. Parathormone, 

 10 units on alternate days, was then given subcutaneously 

 during a period of 45 days. 



The vigor of the reactions returned to some extent during 

 the first portion of this period, but during the latter portion, 

 in spite of the extract, the responses again deteriorated. No 

 tetanic seizures were observed during the administration of 



TABLE 18 

 Bog 856<$ 



Correct responses to positive Met. 120 

 Correct responses to negative Met. 42 

 Average magnitude of C-R to 

 positive Met. 120 



100% 

 38% 



4.-. 



AFTKK TH YKO I'AKATH YKomKCTOMY 



No para- 

 thormone 



75% 

 50% 



During 



administration 



of 

 parathormone 



100% 



'.'4 



Terminal 

 phase; 

 no para- 

 thormone 



66% 



44% 



the substance. The C-R remained weak for 6 weeks after 

 the withdrawal of the extract ; again no tetany was observed. 

 The positive reaction now disappeared completely. Three 

 determinations of the blood serum calcium were made on 3 

 consecutive days, with the calcium values 5.4 mg\, 8.1 mg., 

 and 6.1 mg., respectively. These are below the normal values. 

 Eight days after these determinations were made, typical 

 attacks of tetany began to appear and the dog died in tetany 

 a few days later. 



At autopsy, histological examination of the transplanted 

 parathyroid tissue revealed the presence of a few apparently 

 functional parathyroid cells. 



Table 18 summarizes these results. The efficiency of the 

 positive C-R dropped at once after the operation (100 per 



