GENETIC TYPE AND THE ENDOCRINES 719 



The average magnitude of the C-R was tremendously 

 changed after the hypophysectomy. It dropped at once (9 

 to 1-), was augmented considerably during the anterior lobe 

 extract (to 3), and was maintained during the thyroid extract 

 period (3). During the period of the transplants, the response 

 declined to a new level (to 2), yet this was a great deal above 

 the level in the period when no treatment at all was given 

 (1-). The results are graphically presented in plate 111 and 

 text-figure 128. 



Plate 111 shows records of the typical conditioned food- 

 taking reactions of dog C-l in the normal period (fig. 3), in 

 the period after hypophysectomy (fig. 4), and in the period 

 during the administration of the anterior lobe extract (fig. 5). 

 Notice in figure 3 the normal head movements, alterations of 

 respiratory rate, and copious salivary flow during the Met. 

 120. Note in figure 4 the absence of all three components of 

 the reaction. In figure 5 notice that the stimulus evoked an 

 alert head movement, a change in respiration and a strong 

 flow of saliva closely similar to the normal. It can be seen 

 that the normal responses evoked by the food itself remained 

 unaltered. 



The chart, text-figure 128, shows the course of the experi- 

 ment in detail with the exception of the period of the trans- 

 plants. It is clearly shown that the C-R disappeared almost 

 altogether following the operation and remained so for about 

 1 month. It increased noticeably on the fifth day after the 

 injection of anterior lobe extract was begun, but this gain 

 was lost as the C-R dropped to zero during the continued 

 therapy. On the fourth day after thyroid extract was in- 

 jected the response began to return, and on the twenty-third 

 day it was maximal. The C-R fell rapidly after the extract 

 was withdrawn, and in 20 days its value was zero. 



The autopsy at the end of the experiment showed the 

 pituitary to be entirely absent. The transplants in the pectoral 

 muscles had been completely resorbed. 



Dog C-2 $ , bassethound X shepherd F 3 , The effects of hypo- 

 physectomy in dogs 492 and C-l were considered a result of 



