720 



O. D. AXDEKSOX 



the absence of the anterior rather than the posterior lobe 

 of the gland. The experiments did not, however, offer proof 

 that such was the case, and it was considered of interest to 

 carry out an additional experiment, in the nature of a control, 

 in which the posterior lobe alone was removed, the anterior 

 portion being- left essentially undisturbed. This was success- 

 fully done in dog C-2. 



- Dog C -li F3 Basset-Shepherd 



WtBKHA'n 



Text-figure 128. Chart showing the effect of complete hypophysectomy and of 

 the subsequent administration of anterior pituitary extract and thyroid extract 

 on the conditioned salivary reflex in dog C-l. As in the case of thyroidectomy, 

 note that the reaction here also collapses post-operatively. It is revived transitorily 

 by the anterior pituitary extract but the effect disappears during a continuation 

 of the therapy. Thyroid extract was then given and produced a noticeable return 

 of the reaction, which subsided after withdrawal of therapy. 



The operation was performed prior to any behavior studies 

 when this animal was only 3 months of age. Salivary con- 

 ditioned reflex trials were begun 4 months later, and were 

 continued for 1 year and 8 months. During this entire time 

 it was clear that the operation had had no effect whatever 

 upon the behavior of the animal. The general reactions outside 

 the laboratory were those of any normal, lively, friendly dog. 

 She was a pet and had been born and reared in the laboratory. 

 There were no signs of shyness, and her general health was 

 good. 



