GENETIC TYPE AND THE ENDOCRINES 731 



The behavior of this animal merits the following detailed 

 description. He ran incessantly in the pen with tongue lolling, 

 and barked frenziedly. When the observer came to the door 

 he growled and barked, slowly backing away, and when the 

 pen was entered he ran quickly into the cage or into a dark 

 corner. He crouched, trembled and urinated when the leash 

 was put about his neck, and clashed this way and that in 

 attempting to escape. But he always wagged his tail when 

 patted. He was very watchful and alert towards everything 

 about him. When put into the straps for experiment and 

 left alone, he would immediately plunge forward or suddenly 

 back up, and struggle violently to free himself, frequently 

 getting tangled in the straps. In the fits of violent struggling 

 he would bite at the recording string, the electrodes and 

 the restraining straps. On two occasions he snapped at the 

 observer's hands when being calmed. His motor responses 

 to the metronome followed by the shock were extremely 

 vigorous, diffuse and often violent, and were always quite 

 prolonged. Such responses often began when he heard the 

 drum starting. 



The dog was trained for 3 months before the critical ex- 

 periment. The 0-R was established with remarkable rapidity 

 in 3 trials and thereafter readily appeared at every trial. 



The adrenalectomy was performed in two stages. The gland 

 on the right side was removed at the first stage and, after 2 

 weeks, during which time the animal seemed to recover com- 

 pletely, the left adrenal was removed. In order to protect 

 the animal against the consequences of the second operation, 

 an extract of the suprarenal cortex, Esehatin, 21 cc, was 

 administered subcutaneously just prior to the operation. 



When the C-R tests were taken up again 10 days after 

 the operation, behavior was not affected in any observable 

 way, and no effect was noticed for a period of 11 days. At 

 the end of this period, and 21 days after the operation, be- 

 havior generally became very noticeably disturbed. The re- 

 actions during this period also merit detailed description 

 and should be compared with the foregoing description in 



