GEXETIC TYPE AND THE EXDOCRINES 733 



The average magnitude of the reflex was essentially un- 

 affected in the first period (75 to 82) but was enormously 

 weakened in the second (to 9), and during the therapy the 

 vigor of the response was restored to about half the normal 

 (35). 



The graphic records in plate 112 show the motor responses 

 in three phases of the experiment; the normal period (fig. 1), 

 the period of the deterioration of the response after the 

 adrenalectomy (fig. 2) and the period of its partial restora- 

 tion during the cortical extract (fig. 3). Notice in figure 1 

 the enormous vigor of the head movements, the body move- 

 ments, the tremendously disturbed respiration and the exag- 

 gerated, diffused struggling evoked at once by the Met. 120 

 and continuing long after the stimulus and shock had ceased. 

 The records in figure 2 contrast strikingly with those of 

 figure 1. In figure 2 two stimuli are shown together with the 

 5 minute interval between them. The first Met. 120 and shock 

 evoked no motor reaction. The animal stood immobile during 

 the interval, and the second stimulus and shock evoked only 

 weak and retarded reactions of the head, the respiration and 

 the foreleg. Note the absence of the after discharge in the 

 leg response. Figure 3 shows revival of the reactions during 

 the Eschatin. Notice that the head and body movements, 

 the respiration disturbance and the leg movements are almost 

 ms vigorous and prolonged as normal. 



In spite of the administration of the extract of the supra- 

 renal cortex, the general reactions became weaker and more 

 retarded on the third day. Every gross body movement was 

 exceedingly slow in execution. All food was refused. The 

 dog walked about but little in the pen and was found lying- 

 down most of the time. At this time, pinching the legs with 

 forceps or pricking between the toes with a needle (a very 

 tender spot in the dog) or applying a moderate shock to 

 the toe pad evoked no observable reaction in most cases, but 

 in very few there was a noticeable twitch of the flexor muscles 



