EFFECTS OF IONS UN VASCULAR SMOOTH MUSCLE 



I l6l 



regulates the case with which it is extruded permit> 

 very fine control of the sodium gradient. 



4) The role of cell volume remains to be assessed 

 both in acute and chronic changes of vascular smooth 

 muscle tension. This is self-evident. We are repeating 

 this point at this time to emphasize the fact that this 

 problem cannot be dealt with properly until such time 

 as water movements can be accurately measured (65, 

 195)- 



SUMMARY 



The detailed supporting evidence leading to our 

 final theoretical interpretation is contained in the body 



of this chapter. In order to underline our intention 

 we have referred briefly to some essential evidence 

 which cannot be easily explained in any alternate 

 way. It is our opinion that most of the apparentlv 

 complex material presented can be temporarily but 

 usefully rationalized by reference to the theory pre- 

 sented. It is allied with general ionic theory as it 

 applies to other contractile elements (113) modified 

 to serve the special needs of this particular tissue. 



We conclude that vascular smooth muscle tension 

 depends on ionic distributions and mobilities across 

 the cell membrane. The transmembrane equilibra- 

 tion of both sodium and potassium has been stressed 

 as has the possibility of a direct link with calcium. 



REFERENCES 



I Al.KKSANDROW, D., W. W'VSZNACKA, AND J. GaJEWSKI. 



Studies on the mechanism of hypotensive action of 



chlorothiazide. New Engl. J. Med. 260: 51, 1959. 

 2. Allen, F. M., and J. \V. Sherrill. The treatment of 



arterial hypertension. J. Metabolic Research 2: 429, 1922. 

 3 Ambache, N. Interaction of drugs and the effect of 



cooling on the isolated mammalian intestine. ./. Physiol. 



104: 266, 1946. 



4. Ambard, L., and E. Beaujard. Causes de l'hypertension 

 arterielle. Arch. gen. Med. 1 : 520, 1 904. 



5. Axelsson, J. Further studies of the dissociation between 

 action potentials and the contractile mechanism in 

 smooth muscle. J. Physiol. 152: 16P, i960. 



6. Axelsson. J., and E. Bulbring. Some means of abolishing 

 the tension response in smooth muscle during continued 

 electrical activity at the cell membrane. J. Physiol. 1 49 : 

 50P, 1959. 



7. Bacq, Z. M., and A. M. Monnier. Recherches sur la 

 physiologie et la pharmacologic du systeme nerveux 

 autonome. XV. Variations de la polarisation des muscles 

 lisses sous l'influence du systdme nerveux autonome et de 

 ses mimetiques. Arch, intern, physiol. 40: 467, 1935. 



8. Baer, J. E., H. F. Russo, and K. H. Beyer. Saluretic 

 activity of hydrochlorothiazide i6-chloro-7-sulfamyl- 

 3,4-dihydro-i ,2 ,4-benzothiadiazine-i , 1 -dioxide j in the 

 dog. Proc. Soc. Exptl. Biol. Med. 100: 442, 1959. 



g. Barr, L. M. Distribution of ions in intestinal smooth 

 muscle. Proc. Soc. Exptl. Biol. Med. 101 : 283, 1959. 



10. Barr, L. M., D. F. Bohr, and V. Headings. Recovery 

 of carotid artery strips from cold storage. Federation Proc. 

 19: 258, i960. 



1 1 . Bevan, J. A. The use of the rabbit aorta strip in the 

 analysis of the mode of action of /-epinephrine on vascular 

 smooth muscle. J. Pharmacol. Exptl. Therap. 129: 417, 

 i960. 



12. Binet, L., and M. Burstein. Action de quelques cations 

 sur le tonus des vaisseaux peripheriques. Compt. rend. soc. 

 biol. 142: 1363, 1948. 



13. Bohr, D. F., D. C. Brodie, and D. H. Cheu. Effect 

 of electrolytes on arterial muscle contraction. Circulation 



n- 746. 195°- 



14. Bohr, D. F., and P. L. Goulet. A direct recording of 



tension from isolated arteriolar smooth muscle. Physiologist 

 3 (No. 3) : 25, 1 960. 



15. Born, G. V. R. The relation between the tension and 

 the high-energy phosphate content of smooth muscle. 

 J. Physiol. 131 : 704, 1956. 



16. Born, G. V. R., and E. Bulbring. The movement of 

 potassium between smooth muscle and the surrounding 

 fluid. J. Physiol. 131: 6go, 1955. 



1 7. Bozler, E. Conduction, automaticity and tonus of 

 visceral muscles. Experientia 4: 213, 1948. 



18. Braun-Menendez, E. Water and electrolytes in experi- 

 mental hypertension. In: Ciba Foundation Symposium on 

 Hypertension. Boston: Little, Brown, 1954, p. 238. 



19. Bulbring, E. Membrane potentials of smooth muscle 

 fibres of the taenia coli of the guinea-pig. J. Physiol. 125 

 302, 1954. 



20. Bulbring, E. Correlation between membrane potential, 

 spike discharge and tension in smooth muscle. J. Physiol. 

 127: 9P, 1955. 



21. Bulbring, E. Correlation between membrane potential, 

 spike discharge and tension in smooth muscle. J . Physiol. 

 128: 200, 1955 



22. Bulbring, E., and H. Lullmann. The effect of metabolic 

 inhibitors on the electrical and mechanical activity of 

 the smooth muscle of the guinea-pig's taenia coli. .7. 

 Physiol. 136: 310, 1957. 



23. Burget, G. E., and M. B. Visscher. Variations of the 

 pH of the blood and the response of the vascular system 

 to adrenalin. Am. J. Physiol. 81 : 113, 1927. 



24. Burnstock, G. Membrane potential changes associated 

 with stimulation of smooth muscle by adrenalin. Xature 

 186: 727, i960. 



25. Burnstock, G, and C. L. Prosser. Conduction in 

 smooth muscles : comparative electrical properties. Am. J. 

 Physiol. 199: 553, i960. 



26. Burnstock, G, and R. W. Straub. A method for study- 

 ing the effects of ions and drugs on the resting and action 

 potentials in smooth muscle with external electrodes. 

 J. Physiol. 140: 156, 1958. 



27. Cameron, D. R, D. M. Dunlop, R. Platt, M 1. 

 Rosenheim, and E. P. Sharpey-Schafer. The rice diet 



