1246 



HANDBOOK OF PHYSIOLOGY 



CIRCULATION II 



(3) Infections 



(a) Bacterial 



(b) Rickettsial 



(c) Viral 



(4) Splenomegaly 



(a) Band s syndrome 



(b) Felty's syndrome 



(c) Gaucher's disease 



(d) Hodgkin's disease 



(e) Leukemia 



(5) Malignancy 



(6) Drugs and chemical agents 



(a) Allyl-isopropyl-acetyl-carbamide 

 (Sedormid) 



(b) Arsenic 



(c) Benzene 



(d) Bismuth 



(e) Certain foods, such as orris root 



(f) Chloramphenicol 



(g) Dichloro-diphenyl-trichloro-ethane 

 (DDT) 



(h) Digitoxin 



(j) Dinitrophenol 



(j) Ergot 



(k) Gold 



(1) Hair dyes 



(m) Iodine 



(n) Methylphenylethyl hydantoin 



( Mesantoin) 

 (o) Nitrogen mustard 

 (p) Pertussis vaccine 

 (qj Phenol 

 (r) Phenolphthalein 

 (s) Phosphorus 

 (t) Quinidine 

 (u) Quinine 

 (v) Snake venom 

 (w) Streptomycin 

 (x) Sulfa drugs 

 (y) Triethylenemelamine 

 (z) Trimethadione 



(7) Physical factors 



(a) Heat stroke 



(b) Radiation 



(c) Burns 



B. Nonthrombocytopenic purpura 

 1 . Primary 

 a. Senile 



b. Purpura simplex 



c. Hereditary hemorrhagic diathesis 

 2. Secondary 



a. Stasis — increased venous pressure 



b. Traumatic or mechanical 



c. Allergic or anaphylactoid 



( 1 ) Schoenlein-Henoch purpura 



(2) Purpura fulminans 



(3) Other 



d. Skin diseases 



e. Chemical agents 



(1) Acetophenetidin (Phenacetin) 

 1 2 ) Atropine 



(3) Belladonna 



(4) Bismuth 



(5) Chloral hydrate 



(6) Iodine 

 (71 Mercury 



(8) Penicillin 



(9) Quinine 



( 10) Salicylic acid 



lii) Various anticoagulants 



f. Systemic diseases and infections 



( 1 ) Nephritis 



1 2 ) Purpura fulminans 



(3) Septicemia 



(4) Enanthema 



(5) Scarlet fever 



(6) Other bacterial diseases 



(7) Rickettsial diseases 



(8) Viral diseases 



g. Avitaminosis 



( 1 ) Scurvy 



(2) Vitamin P deficiency 



(3) Vitamin K deficiency 

 14) Other vitamin deficiency 



h. Cryoglobulinemia 



II. INCREASED PERMEABILITY OF VESSELS 



A. Allergic urticaria 



B. Angioneurotic edema 



C. Inflammation 



D. Physical irritants 



1. Trauma 



2. Cold 



3. Heat 



E. Scrum sickness 



REFERENCES 



1 . Abramson, D. Diagnosis and Treatment of Peripheral Vascular 

 Disorders. New York: Hoeber-Harper, 1956. 



2. Adson, A., and G Brown. The treatment of Raynaud's 

 disease by resection of the upper thoracic and lumbar 

 sympathetic ganglia and trunks. Surg. Gynecol. Obstet. 



48:577. '929- 



3. Allen, E., N. Barker, and E. Hines. Peripheral Vascular 

 Diseases (2nd ed.). Philadelphia: Saunders, 1956. 



4. Allen, J., P. Moulder, D. Emerson, C. Basinger, J. 

 Landv, and D. Glotzer. Physiology of intravascular 

 coagulation in health and disease. Surg. Clin. North 

 Am. 37: 1473, 1957- 



5. Barker, N, E. Hines, and W. Craig. Livedo reticularis. 

 A peripheral arteriolar disease. Am. Heart J. 21 : 592, 1 941 . 



6. Boas, E. Capillaries of extremities in acrocyanosis. J. Am. 

 Med. Assoc. 79: 1404, 1922. 



