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HANDBOOK OF PHYSIOLOGY 



CIRCULATION II 



findings to in vivo coagulation remains unknown. 

 Recently Poole (164) has emphasized the difference 

 between clotting and thrombosis and has pointed 

 out that factors important in clotting may be un- 

 important in thrombosis. Under the electron micro- 

 scope, clots and thrombi are different in structure. 

 The thrombus contains areas of closely packed plate- 

 lets while the clot contains predominantly red cells 

 and a few platelets distributed at random in a fibrin 

 network. It has been shown (44) that the coagulum 



formed when blood is made to flow through a closed 

 circular loop of plastic tubing mounted on a rotator 

 resembles a natural thrombus. In this system the 

 unesterified long-chain saturated fatty acids accel- 

 erate thrombus formation, while the polyunsaturated 

 and shorter chain fatty acids are inactive. More 

 information is needed about the relationship between 

 clotting and thrombosis before a decision can be 

 made concerning the part played by dietary fat and 

 lipemia in the mechanism of thrombosis. 



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