CIRCULATION IN SKELETAL MUSCLE 



I 3 8. 



muscle metabolism, of histamine and especially of 

 acetylcholine all were followed by widening of the 

 femoral artery. 



Hilton (121, 122) compared the effects of a variety 

 of drua;s and procedures on postcontraction hyperemia 

 and on the postcontraction dilatation of the femoral 

 artery. The actions of drugs on these two processes 

 resembled each so closely as to suggest strongly that 

 they had a common mechanism. He noted also that 

 the dilator response traveled slowly along the wall 

 of the artery at about 10 cm per sec. Intra-arterial 

 injections into the muscle of acetylcholine, histamine, 

 bradykinin, and nicotine were all followed by intra- 

 and extramuscular arterial vasodilatation. However 



intra-arterial injection of ATP causes only intra- 

 muscular vasodilatation; he did not think that ATP 

 could be concerned with the dilator response which 

 accompanies muscular contraction (125). 



5) D'Silva & Fouche (69) found that shunting 

 the blood from the artery to the vein causes widening 

 of the artery proximally. They think that the dilata- 

 tion of the artery in exercise may not be due to 

 metabolites but to a change in the rate of flow. 



4) It seems important to bear in mind that muscle 

 blood flow, work done, and oxygen consumption are 

 closely related, though we do not understand the 

 nature of the underlying mechanism. 



REFERENCES 



1. Abramson, D. I., and S. M. Fierst. Peripheral vascular 

 responses to exercise in the hyperthyroid state. J. Clin. 

 Invest. 20: 517, 1941. 



2. Abrahams, V. C, and S. M. Hilton. Active muscle 

 vasodilatation and its relation to 'flight and fright' 

 reactions in the conscious animal. J. Physiol.. London 

 140: 16P, 1958. 



3. Abrahams, V. C, S. M. Hilton, and J. L. Malcolm. 

 Sensory input to the hypothalamic and mesencephalic 

 regions subserving the defence reaction. J. Physiol., London 

 149: 45P, 1959. 



4. Abrahams, V. C, S. M. Hilton, and A. Zbrozvna. 

 Active muscle vasodilatation elicited by mesencephalic 

 stimulation. Its relation to the defence reaction. J. 

 Physiol., London 148: 32 P, 1959. 



5. Allen, W. J., H. Barcroft, and O. G. Edholm. The 

 action of adrenaline on the blood vessels in human 

 skeletal muscle. J. Physiol., London 105: 255, 1946. 



6. Allwood, M. J., and A. F. Cobbold. Lactic acid release 

 by intra-arterial adrenaline infusions before and after 

 dibenyline, and its relationship to blood flow changes in 

 the human forearm. J. Physiol., London 157: 328, 1961. 



7. Allwood, M. J., and J. Ginsburg. The effect of dibeny- 

 line on the vascular response to the sympathomimetic 

 amines in the forearm. J. Physiol., London 147: 57P, 1959- 



8. Anrep, G. V., and G. S. Barsoum. Appearance of 

 histamine in the venous blood during muscular con- 

 traction. J. Physiol., London 85: 409, 1935. 



9. Anrep, G V., G. S. Barsoum, M. Talaat, and E. 

 Wieninger. Further observations on the release of 

 histamine by skeletal muscles. J. Physiol., London 96: 



->4°. '939- 



10. Anrep, G. V., A. Blalock, and A. Samaan. Effect of 

 muscular contraction upon blood flow in skeletal muscle. 

 Proc. Roy. Soc., London, B. 114: 223, 1934. 



11. Anrep, G. V., and E. von Saalfeld. The blood flow 

 through skeletal muscle in relation to its contraction. J. 

 Physiol., London 85: 375, 1935. 



12. Assmussen, E. and M. Nielsen. Cardiac output during 



muscular work and its regulation. Physiol. Revs. 35: 778, 



'955- 



13. Baetjer, A. M. The relation of the sympathetic nervous 

 system to the contractions and fatigue of skeletal muscle 

 in mammals. Am. J. Physiol. 93: 41, 1930. 



14. Barcroft, H. Action of epinephrine in man. Trans., 

 Fourth Conf. on Shock and Circulatory Homeostasis. New York : 

 Josiah Macy Jr. Foundation. 1954, 9. 



1 5. Barcroft, H., K. D. Bock, H. Hensel, and A. H. Kitchin. 

 Die Muskeldurchblutung des Menschen bei indirekter 

 Erwarmung und Abkiihlung. Pfliigers Arch. ges. Physiol. 

 261: 199, 1955. 



16. Barcroft, H., J. Brod, Z. Heil, E. A. Hirsjarvi, and 

 A. H. Kitchin. The mechanism of the vasodilatation in 

 the forearm during stress (mental arithmetic). Clin. Sci. 

 19 : 577. i960. 



17. Barcroft, H., and A. F. Cobbold. The action of adrena- 

 line on muscle blood flow and blood lactate in man. J. 

 Physiol., London 132: 372, 1956. 



18. Barcroft, H., and A. C. Dornhorst. Blood flow re- 

 sponses to temperature and other factors. Ciba Found. 

 Symp., Peripheral Circulation Man. 1954. 



19. Barcroft, H., and A. C. Dornhorst. Blood flow through 

 the human calf during rhythmic exercise. J. Physiol., 

 London 109: 402, 1949. 



20. Barcroft, H., and O. G. Edholm. The effect of tem- 

 perature on blood flow and deep temperature in the 

 forearm. J. Physiol., London 102: 5, 1943. 



21. Barcroft, H., and O. G. Edholm. On sympathetic 

 vasoconstrictor tone in human muscle. J. Physiol., London 

 102: 21, 1943. 



22. Barcroft, H., and O. G. Edholm. On the vasodilatation 

 in human skeletal muscle during post-haemorrhagic 

 fainting. J. Physiol., London 104: 161, 1945. 



23. Barcroft, H., O. G. Edholm, C. A. Foster, R. H. Fox, 

 and R. K. Macpherson. The effect of nerve block on 

 forearm blood flow. J. Physiol., London 132: 16P, 1956. 



24. Barcroft, H., O. G. Edholm, J. McMichael, and E. P. 

 Sharpey-Schafer. Post-haemorrhagic fainting. Lancet 

 1:489, 1944. 



