47-4 
action noted upon those organs, and the glands in connection with this tract, is, so 
far as known, reflex and sympathetic. 
On Animals.—Among other experiments with this drug upon animals, those 
of Dr. Anstie seem to be the most characteristic. He found, resulting from his 
many applications of an alcoholic solution to the peritoneal cavity direct, that no 
local inflammation arose, although an intense hyperemia occurred in the duo- 
denum especially, and the whole of the small intestine, even going so far as to 
cause a breaking down of the tissues and resulting ulceration, causing discharges 
of glairy mucus streaked with blood; this hyperemia ceased usually at the ileo- 
cecal valve. ost mortem the mucous-membranes were found inflamed and cov- 
ered with bloody mucus. Other observers noted that retching, salivation, and 
emesis, followed by purging, colic, and intense tenesmus, with low pulse, and rapid 
exhaustion followed the administration of the drug. 
On Man.—Here the same action takes place, but extends to the rectum with 
sufficient intensity to cause prolapsus and hemhorrhoids. ‘The first effect of the 
drug is an excitation of salivary and biliary secretions, foilowed by torpor and 
icterus. The symptoms of disturbance caused by the drug in doses varying from 
Y%{ to % grains of “ podophyllin,” and in persons working in the dust of the dried 
root, are substantially as follows: Inflammation of the eyes, soreness and pustula- 
tion of the nose; salivation and white-coated tongue; extreme nausea, followed 
by vomiting; severe pains in the transverse colon and abdomen, followed by an 
urgent call to stool ; thin, offensive, copious stools ; weak pulse, prostration, drowsi- 
ness, and cold extremities. Tg 
DESCRIPTION OF PLATE 17. 
1. Whole plant, once reduced, Newfield, N. Y., May 2oth, 1880. 
2. Flower. 
3. Bud, showing sepals. 
4. Pistil. 
5. Pistil in section (enlarged). 
6. Pistil in horizontal section (enlarged). 
7. One of the lobes of the stigma (enlarged). 
8. Anther (enlarged). 
9. Pollen; side and end views x 200. 
10. Fruit. 
