VETERINARY MEDICINE. 579 



vaccination against rabies; immunizing against African liorse siclcness; vaccine 

 tlierapy; pyocyanase; agglutination, precipitation, and complement fixation; 

 anaptiylaxis ; destruction of mice and rats withi bacteria; and a survey of tlie 

 commercial sera, diagnostic sera, bacterial products, and vaccines for veterinary 

 medical purposes. 



Immune sera, C. F. Bolduan (Netv York and London, 1911, 4. ed., rev. and 

 enl., pp. XI+226, figs. 10). — Tliis is the fourtli edition of this worli (E. S. R., 

 20, p. 1080) which has been entirely rewritten, and enlarged and brought up 

 to date. The book, while it presents Ehrlich's views at length, shows wherein 

 and why this investigator differs from others. 



Its chapters contain discussions of antitoxins, agglutinins, bacteriolysins and 

 hemolysins, precipitins, cytotoxins, opsiuins, snake venoms and their antisera, 

 anaphylaxis, infection and immunity, bacterial vaccines, leucocyte extracts in 

 the treatment of infections, and principles underlying treatment of syphilis 

 with Salvarsan. Appendixes present (a) the Wassermann test for syphilis, 

 (b) Noguchi's modified Wassermann reaction, (c) blood examination prepara- 

 tory to transfusion, and (d) the conglutination reaction, the Much-Holzmann 

 cobra venom reaction, the meiostagmin reaction, Weil's cobra venom test in 

 syphilis, and antitrypsin determinations. 



Immune bodies and biological reactions, A. Eichorn {Amer. Jour. Yet. 

 Med., 6 {1911), Xo. 11, pp. 803-817). — A clear, concise discussion of this sub- 

 ject, with particular regard to veterinary medicine. 



On the local production of antibodies, L. Hektoen {Jour. Infect. Diseases, 

 9 {1911), No. 2, pp. 103-114, fig. 1). — "The results obtained from the experi- 

 ments recorded in this article do not point to any local production of specific 

 antibodies in dogs injected with goat or rat corpuscles, at least not so far as 

 concerns the tissues about the anterior chamber of the eye, the tissues of the 

 pleura, and the subcutaneous tissues." 



Visible detection of antigens; antibody fixation in vitro; the epiphanin 

 reaction, W. Weichardt {Miinchen. Med. Wchnsclir., 58 {1911). No. 31, pp. 

 1662, 1663). — A polemic in regard to the epiphanin and meiostagmin reactions. 

 Further studies of antistreptococcus serum, G. H. Weaver and Ruth Tun- 

 NiCLiFF {Jour. Infect. Diseases, 9 {1911), No. 2, pp. 130-146). — "Antistrep- 

 tococcus serums rapidly lose their opsonic ix)wer, which may for some time be 

 largely restored by the addition of fresh human or guinea-pig serum. 



" Guinea pigs may be protected against virulent cultures of streptococci by 

 previous injection of antistreptococcus serums. The protective power of 

 immune serums continues so long as they can be reactivated by fresh serum. 

 Injections of immune serums in guinea pigs may be followed by increased 

 activity of leucocytes of short duration and by an increased, opsonic power for 

 streptococci in the blood serum persisting for about 10 days. The immunity 

 in guinea pigs produced by injection of immune serum persists for about 8 

 days. 



" Of 3 fresh commercial serums manufactured in the United States which 

 were tested 2 were active and 1 inactive. The 2 European serums wei'e 

 active. Fresh normal human serum and fresh human serum from persons in- 

 fected with streptococci are able to reactivate antistreptococcus serums. This 

 indicates that such serums may have some protective and curative effect in 

 man in cases of streptococcus infections. 



" The siDecific antistreptococcus bodies are resistant to heat and chemicals 

 (tricresol, 0.4 per cent chloroform) and are closely associated with the 

 pseudoglobulins of the immune serum. It would be desirable to have some 

 guaranty of the activity of antistreptococcus serums offered for sale." 



