884 EXPERIMENT STATION EECOED. 



deemed liie simplest and most convenieiit method for diagnosing: glanders iu a 

 large number of animals, and is very certain. Occult cases can be easily de- 

 tected by this method. In this work a comparative study was made between the 

 ophthalmo, cutaneous, subcutaneous, precipitation, agglutination, and comple- 

 ment fixation methods. 



Reduction of virulence in a strain of Trypanosoma hippicum selected frora 

 a g'uinea pig-, S. T. Darling (BuL Soc. Path. Exot., 5 (1912), IVo. 3, pp. 184- 

 187). — "A strain of T. hippicum thnt had survived in a guinea pig the excep- 

 tionally long period of 336 days showed upon subinoculation on the two hun- 

 dred and seventy-ninth and three hundred and thirty-sixth day very feeble 

 pathogenic pofs'ers when compared with all other strains, and with the same 

 strain at an earlier period of the infection in the guinea pig. 



" The reduction of the A-irulence was temporary, for after residence in a mule 

 its virulence for mice, rat, and guinea pig was regained." 



Experimental infection of the mule with. Trypanosoma hippicum by means 

 of Musca domestica, S. T. Darling {Jour. Expt. Med., 15 (1912), No. 4, pp. 

 365, 366). — A brief account of this work has been previously noted (E. S. R., 

 26, p. 056). 



Investig'ation of viruses obtained from cases of human tuberculosis other 

 than lupus, A. S. Griffith (Roij. Com. Tuberculosifi. Final Rpt., 11. App.. 1 

 {1911), p. 543, pis. 7, figs. 29). — This volume records the results of investigat- 

 ing new cases of human tuberculosis other than lupus, and includes a full 

 account of the cultural and pathogenic properties of the 2 types of tubercle 

 bacilli isolated from them and of experiments to ascertain whether any of the 

 properties of these bacilli could be altered by residence in the bodies of mam- 

 mals or birds. 



Tabular summaries are^iven of inoculation experiments performed on differ- 

 ent species of animals, together with full post-mortem notes of the larger 

 animals groupetl together according to the virus used. A series of photographs 

 illustrating the types of growth of the cultures is appended. Pictorial charts 

 exhibiting the lesions produced in calves, pigs, and goats by viruses obtained 

 from cases of human tuberculosis other than lupus are included with other 

 similar charts in a supplementary volume. 



Investigations of viruses obtained from cases of lupus, A. S. Griffith 

 {Roy. Com. Tuberculosis, Final Rpt., II, App., 2 {1911), p. 480, pis. 2, figs. 

 22). — This is a study of the cultural characters and pathogenicity (ordinary 

 virulence for calves, rabbits, rhesus monkeys, guinea-pigs, and other species of 

 animals) of the cultures isolated from cases of lupus vulgarus in man. 



Reports on investigations dealing with certain human viruses of irregular 

 type, the excretion of tubercle bacilli in the milk of animals, swine tuber- 

 culosis, and immunity, A. S. and F. Griffith et al. {Roy. Com. Tuberculosis, 

 Final Rpt., II, App., 3 {1911), p. 355, pis. 2, fig. 58).— This A^olume gives the 

 results of 4 investigations. 



" The material used in the investigations with swine were obtained from 63 

 cases of tuberculosis occurring naturally in swine; iu 21 of these the disease 

 was apparently localized to the lymphatic glands (submaxillary and mesenteric) 

 of the alimentary tract from which the material uged for investigation was 

 taken; in 33 the disease was generalized; in the remaining 9 the condition 

 of the rest of the body could not be ascertained with certainty. In every animal 

 in the series with two exceptions the disease appeared to be alimentary in 

 origin. . . . 



" Natural tuberculosis in swine may be the result of infection either with the 

 bovine tubercle bacillus, the human tubercle bacillus, or the avian tubercle 

 bacillus. 



