THE INFLUENCE OF ANORGANIC ANTIMONY- 

 COMPOUNDS ON TRYPANOSOMES 

 IN THE ANIMAL-BODY. 



BY 



M. D. HORST. 



First assistant of the Laboratory for Comparative Pathology at the Leiden University. 

 {Director Prof. Dr. D. A. de Jon^) 



Before coming to the proper subject of my lecture it seems 

 necessary to speak a few words about trypanosomes in general. 

 They were first seen by VALENTIN in 1841 in the blood of a 

 brook-trout. Gruby in 1843 g^-ve them their name derived from 

 the greek verb trupao (to bore) according to their lively boring 

 movement. 



Many species have been discovered since, in warm as well 

 as in cold blooded animals, but it was only when the ominous 

 part they play as agents of infectious diseases was found out. 

 tliat they raised an interest all over the world. 



They are grouped under the protozoa, the unicellular animals 

 and nowadays most authors accept the classification of Döflein 

 who places them among the Plasmodroma, class Mastigophora, 

 underclass Zoomastigina, order Protomonadinae, familie Herpeto- 

 monadidae, underfamily Trypanosominae, genus Trypanosoma. 

 They posses a single flagellum which arises posteriorly, adja- 

 cent to a blepharoplast or kinetic nucleus. The flagellum forms 

 a margin to an undulating menbrane and ends as a free flagel- 

 lum at the anterior end of the body. 



Since Werbitzky succeded, by the aid of a pyronin treatment, 

 in cultivating trypanosomes without blepharoplasts, it must be 

 acknowledged that the latter is not essential for the life of 

 the Protozoon. 



