1 2g 



Rabbits show a more clironical form of the disease. Only at 

 certain fever periods the parasites are to be found in the blood, 

 often in great numbers short before death. 



As first symptom I noticed a swelling of the head. Then fol- 

 lows conjunctivitis, iritis often with hypopyon, rhinitis. Ul- 

 ceration of the testes is frequent in the males. Loss of hair 

 first round the eyes is always present and emaciation adds to 

 give the animal a most pityfull aspect. 



Still some cases take a much faster course and kill the rab- 

 bit before all the symptoms have shown themselves. 



At a postmortem examination the organs seem very little 

 altered. A big spleen is always tq be found and microscopi- 

 cally except the alteration of the blood and the presence of 

 trypanosoma in the blood everywhere, only a perivascular in 

 filtration round the minor vessels in certain parts of the 

 central nervous system. 



As I told you already the trypanosomes are not always to 

 be found in the perepheral circulation. Between two fever pe- 

 riods it is however possible to detect them by injecting a 

 sufficient quantity of the suspected blood into mice rats or 

 dogs, which will promptly develop the disease. This is 

 the way how to make sure wether an animal has been cured 

 or not, though anyhow it is necessary to wait a long time 

 after the symptoms disappaered. 



As you know experiments with trypanosomes have been 

 made in almost every country by the most competent workers, 

 but it was Ehrlich who in the Speyer House at Franfort a/M took 

 experiments on the largest scale and in the most systematic way. 



Before Ehrlich chemotherapeutical questions were principally 

 studied to find a relation between the chemical structure of a 

 curtain stuff at one side, the alteration of the physiological 

 functions of the body, caused by that stuff, on the other. This 

 method gave very good results for symptomatic therapeutics, 

 leading to the discovery of many fever remedies as salicylate 

 of soda, aspirine, phenacetine, antipyrine ant others, besides 

 many soporofics. 



Ehrlich, basing himzelf on his earliest work in tissue-staining 

 tried to find out the distribution of different drugs in the different 

 tissues and during this study conceived the idea that drugs 



