»3« 



curing a tertian malarial fever with only one injection of sal- 

 varsan, when full doses of quinine even injected intramupcu- 

 larly, had failed. 



Except the forming of gametes, things are the same with 

 trypanosomiases as far as arsenic compounds are concerned, 

 thus leading to a combined treatment of arsenic with other 

 medicaments. 



It is a very interesting fact from the biological point of 

 view that arsenic resistant strains of trypanosoma loose their 

 resistant power, when propagating by sexual, anisogamous 

 processus in the rat louse, haematopinus spinulosus. 



Further difficulties in chemotherapeutic experiments arise from the 

 difference that exists between difïerant strains of parasites as to 

 their sensibility for chemical agents, the same with the laboratory 

 animals. Further the difference in virulency of different strains. 



As antimony follows arsenic in the periodic system of elements, 

 it is easily understood why it was chosen for treatment in protozoal 

 diseases. It forms the same oxygen compounds as the arsenic. 



The salts in general are hardly soluble in w^ater, except 

 tartar emetic. On the animal or human body antimony salts 

 act almost in the same way as the arsenic salts. 



Too large doses cause vomiting and profuse diarrhoea. The 

 bloodvessels of all abdominal organs are overfilled with blood, 

 most probably by laming of the splanchnical nerves. Then follows 

 depression of the central nervous system, heartweakness, collaps. 



Albumen and epithelial casts are to be found in the scantily 

 secreted urine and after a short time follows the end. 



It is important to know that, when the grave symptoms have 

 set in there is no chance anymore that the patient will recover. 



The more chronical form of the intoxication shows a gradual 

 loss of power an ever increasing decline, owing to a fatty 

 degeneration of the liver, the kidneys, the muscles and degene- 

 ration of the ganglia in the spinal cord. 



The elimination takes place for the greater part through the 

 kidneys and as Professor Dr. L. VAN Itallie (Leyden) showed, 

 much slower than the elimination of arsenic. He examined the 

 water of a patient treated with tartar emetic by Kavser and 

 me for venereal granuloma and saw the elimination still going 

 on weeks after the last injection. 



