t3â 



Keeping in view the facts already mentioned and knowing 

 too, that the toleration for antimony is not always the same 

 in différents individuals, it is easily understood that antimony, 

 though already used as a remedy by the Arabs and the Greek, 

 was for a long time discredited. 



Till the sixteenth century it was praised as a panacea 

 against a lot of diseases, especially against syphilis. Then the 

 academies of Paris and Heidelberg forbode its use, too many 

 cases of poisoning by antimony being recorded. And now it 

 has come to glory again. 



It was MeSNIL who first recommended its use against protozoal 

 diseases. 



PlIMMER and THOMPSON introduced it in the treatment of 

 trypanosomiases. 



GaSPAR Vianna made use of it in cases of venereal granu- 

 loma and espundia., CaSTELLANI in the tropics and Carona 

 in Europe gave it against kala azar. CASTELLANI prescribed it 

 already a long time against yaws, our framboesia tropica, 

 combined with salicylate of soda and iodide of potassium, the 

 so called yaws mixture. 



In Holland it was lirst given by KaySER and me in 

 a case of venereal granuloma and by BENJAMINS against 

 espundia. 



It is generally injected into the blood, though mixtures and 

 even external application are not without having effect. 



Mostly tartar emetic is chosen. 



From an article by GrEIG in the Indian Journal of Medical 

 Research, I see that in British India very large doses are given. 

 First 2 cc of a one percent solution in sterile salt water, then 

 every day increasing doses till even 12 cc a day and 125 cc 

 in 20 injections, within 29 days. 



This is a very strong treatment. KaySER and I injected a 

 one tenth per cent solution with a three or four days interval 

 and after 27 days, having injected 820 mgrs were obliged 

 to stop for a while, signs of kidney-irritation setting in. 



An exact examination of the water every day is necessary 

 to avoid danger. 



Especially in Leishmanioses it is a brilliant cure but let us 

 not forget that the remedy is not only parasitotrope but also 



