i33 



ôrganotrope and that the toxic dose is not much larger than 

 the curative one. i) 



My own experiments were taken with guinea-pigs and rabbits. 

 First I used tartar emetic, a one percent solution in sterile salt 

 water. The results I show you in these curves (fig. 2). 



I treated the animals with big doses, with small doses, with 

 long and short intermissions, but the result was the same, all died 

 after a longer or shorter illness. Still it is possible to prolong 

 their life for months and this experience showed me that is was 

 possible to keep ^the strains alive with less costs than before. 



I simply treat the animals with just as much tartar emetic 

 as is sufficient to keep them alive, the trypanosomes returning 

 regularly in the peripheral circulation. 



For guinea-pigs the dose is about 0,5 — 0,75 pro 100 grams, 

 for rats about the same. 



Very soon, sometimes ten minutes after the injection the 

 parasites disappear from the blood and no doubt the greater 

 part is distroyed. Some specimina however seem to escape. 

 This leads us to expect that the remedy does not reach them 

 and it would be interesting to know wether the antimony 

 penetrates into the spinal fluid or not. 



Of course all kinds of antimony compounds have been tried. 



As a rule found by ClOETTA and Brunner (Zurich) the 

 three worthy compounds are very parasitotrope and very 

 organotrope, the five worthy compounds just the reverse, but 

 there is one exception, the Sb203, antimony trioxyde. 



This white powder showed in the hands of KOLLE a good 

 remedy and not very dangerous for laboratory animals. 



It must be observed that in former publications on this 

 subject, for in stance of SOLEWEITSHUK, quite the contrary 

 was maintained. 



KOLLE easily succeeded in curing mice from trypanosomiasis 

 by injecting a compound mixture of stibiumtrioxyde and after 

 him HOFMANN published very remarkable results obtained with 

 rabbits, infected with ngana and dourine, having cured all his 

 animals with only one injection, containing from 40 — 100 mgrs. 

 of Sb2 O3. 



^) We just received a letter from our patient that he was entirely cured. 



