135 



The powder was mixed up in sirupus simplex (pharmacopoea 

 helvet.) 100, pulvis gummi arab 7,5, carefully mixed in a mortar 

 and sterilised at 120" Celsius for fifteen minutes. Usually in one 

 cubic cM. were mixed 150 mgrs. of Sb203. 



Before injection in the marginal vein the mixture must be 

 warmed for two or three minutes in boiling water in order to 

 drive the air out for fear of embolus. During this time the 

 oxyde will not precipitate. 



Professor Dr. F. A. H. SCHREINEMAKERS (Leiden) was so 

 kind to give me a sufficient quantity of pure Sb203 for which 

 I duly thank him here. Though my results were not so succesfuU 

 as Hoffmann's I still succeeded in curing 2 rabbits out of 9 

 with only one injection, a real therapia sterilisans magna. 



One or two days after the injection the animals seem to be 

 very ill and then very soon recover. 



I observed them for at least six months, several times 

 injected their blood into mice but they never showed signs of 

 trypanosomiasis anymore. 



Without doubt this remedy has a very remarkable influence 

 on the parasites, but its insolubility is a great drawback. 



A certain quantity of the mixture is always left in the syringe 

 making the dosage inaccurate. Then there is the chance of 

 embolic processus setting in, either in the marginal vein itself, 

 or much more dangerous in the capillary vessels of the lungs . 



Embolus in the marginal vein was followed bij necrosis of 

 a great part of the external ear, accompanied by an inflamma- 

 tory process that once led to septicaemia and always made 

 the animals very ill. 



In one case (121) death followed on the fifth day after the 

 injection. At the postmortem examination the lungs showed 

 numerous haemorrhagic infarcts, due to capillary embolus with 

 the trioxyd mixture. Dr. H. J. Montagne (Leiden^ was so kind 

 to make a chemical analysis et the lung in question and found 

 about 4 mgrs of Stibium in one of the lobes. 



The remedy was already patented under the name of trixidine. 

 It seems to me that it ought to betested on larger animals. 



A soluble compound would be far more preferable, and will 

 probably to be found among the organic compounds, about 

 which I hope to speak to you at another time. 



10 



