VETERINAEY MEDICINE. 285 



were conducted with 5 mature cows wliicli had been condemned as tuberculous. 

 The details of the experiments including the symptoms of the animals are 

 reported in tabular form, followed by reports of the post-mortem examinations. 

 Disparene was the form of arsenate of lead used. " In the case of cow No. 1, 

 2!) gm., administered at the rate of 1 gm. per day, produced violent symptoms 

 of poisoning. With animal No. 2. 16.5 gm., given in daily doses of 4 gm. per 

 day, caused violent purging, loss of appetite and paresis. No. 3 took 151 gm. 

 in 2, 3 and 4 gm. doses daily before equally marked symptoms of poisoning 

 appeareil. With No. 4, 28.35 gm. given at one dose in capsule at 9.45 a. m. 

 jiroduced toxic effects in less than 24 hours, from which the animal did not 

 recover completely for 6 or 7 days. In the case of No. 5, 56.70 gm. caused death 

 in 69i hours. A study of the records of the 5 animals shows that frecpiently 

 repeated small doses of the arsenate have the same effect in the end as do 

 large nonfatal doses given at one time. In feeding the lead arsenate paste 

 it was found necessary to adopt every conceivable means to induce the cows to 

 take it after a few doses had been given. At first when mixed with the hay 

 or grain it \\as readily eaten, but after a short time the animals would care- 

 fully separate every particle of the paste from the hay or grain and leave it 

 uneaten. . . . When the hay that had been drenched with 1 and 2 oz. of lead 

 arsenate in water was allowed to become thoroughly dried, it was readily eaten 

 by the cows that had previously refused the fresh paste, even when thoroughly 

 mixed with hay and grain, or inclosed without cai)sule inside of pieces of roots 

 and apples." 



Milk was analyzed, and also fed to a calf, but failed to give evidence of the 

 presence of lead or arsenic. I'arts from the different organs of the second 

 animal were analyzed as a composite specimen and found to contain abundant 

 evidence of lead and traces of arsenic. A brief summary is given of the symp- 

 toms of acute and chronic poisoning, diagnosis, prognosis, and treatment. 



A moderately heavy growth of herdsgrass grown on an area 35 ft. in diameter 

 was found, when thoroughly hayed, to weigh 50 lbs. From this it is computed 

 that with a drip of 1 gal. in 10 of a mixture of 10 lbs. of the arsenate to 100 

 gal. of water, each 10 lbs. of the hay would carry 9.06 gm. of the arsenate 

 paste, or practically one-half of that amount of the dried arsenate. The author 

 does not consider it probable that a single feeil of such hay would produce 

 serious effects but that the continuous feeding of it for several days in succes- 

 sion would do so. Judging from the experience in the feeding of treated hay, 

 it is thought that the animals would eat sufficient to cause fatal poisoning. 



In these experiments the author was unable to detect an individual sus- 

 ceptibility to the action of the poison. It is thought that the harmless effects 

 of arsenate of lead on a horse noted by Kirkland (E. S. R., 10, p. 567) is ac- 

 counted for in part at least by the natural nonsuseeptibility of the animal to the 

 action of lead, to which ruminants appear to be particularly susceptible. 



Diseases of the stomacli and bowels of cattle, A. J. Mukray ( U. iS*. Dept. 

 Agr., Bur. Anim. Indus. Circ. 68, rev., pp. l.'/). — A reprint with slight changes 

 from the Special Report on Diseases of Cattle previously noted (B. S. R., 21, 

 p. 283). 



The Grand Traverse disease or Lake Shore disease, C. D. Smith (Michigan 

 Sta. Spec. Bui. 50, pp. 3-10). — Complaints having been made to the station in 

 1904 of the prevalence of this disease about West Olive in Ottawa County and 

 elsewhere, animals were purchased for examination and treatment. Investi- 

 gations have also been conducted under the Adams fund and are here reported 

 in detail. A report of a visit to the section where the disease occurs by Dr. W. 

 Giltner is appended to the account. 



