582 EXPERIMENT STATION HKcOHl). 



Experimental research in dourine, with particular consideration as tO 

 the atoxyl treatment, riii.KNiHTii mimI Woniii; (.1/7^ h. (Ixiidht.'itiDil., .i!) 

 (y.mS), .\r>. „'. iip. J,0S-J,5U fif/x- -i: <il>'<- ill -loin: Trop. Vet. SH., .', { l<)09), No. S, 

 p. J/Sf)). — Tlic Mutliors conclude from the invcstif^iilinns licic rciMH-tcd 11i;it it is 

 not i)ossil»h' to picM'iit the onset of experimental ddiirinc li.\ I lie previous injec- 

 tion of atoxyl, tliouuli its ndiuiuislration is successful in preveutiui; the disease 

 ill inoculated animals providing; if is done immediately after infection. It may 

 succei'd in i-iirint,' or freeiui,' llie animal fi'diii pnrasites diirin.i,' tlie <-<)urse <if tlie 

 disease. 



Iliirses and dogs can not take a sufficiency of atoxyl to completely kill all 

 trypanosomes, but rabbits, rats, and mice can withstand comparatively lars:e 

 doses. The method of administerini,' by unguent appears tn be preferable to 

 administration in solution. 



A biblioiiraphy of (iT titles is aiipended. 



Biliary fever or malig'nant jaundice of the dog (canine piroplasmosis), 

 W. JoUKTT (.1.'//'. '/oiti: ('(tpc (idod IJopc, .i.') (I'Ji)'.)). .Vo.y. .'/, pj). 'i.t'.)-.'i) I ; .'>. iiii. 

 582-,'>S.'i). — The author reports in detail the results of injections with trypan- 

 blau of lo experimentally and <» naturally infected dojrs. Except in the case 

 of 2 dogs almost in extremis when received, the treat lueiit i)roved to be an 

 unqualified success. 



"Six dogs infected experimentally with biliary fever (by injection of viru- 

 lent blood), and subsequently treatetl with one injection of trypanblau, all 

 recovered. Four dogs injected in like manner, but which did not receive drug 

 treatment, all died. One experimentally infected dog in which the treat- 

 ment was attempted by the administration of a dose of trypanblau by the 

 mouth also succumbt^l. One dog infected experimentally and injected 3 days 

 later subcutaneously with half dose of trypanblau before parasites had ai> 

 peared in its blood remained well, as did also an animal which received a dose 

 of trypanblau and 6 days later an injection of virulent blood. . . . Four dogs 

 very ill and manifesting severe symptoms of biliary fever (red colored urine, 

 anemia, yellow colored membranes, etc.), under treatment by injection of try- 

 jjanblau all recovered." 



One of the dogs which recovered i-esiste<l an inoculation of virulent blood 

 and was evidently immune. Investigations of the action of trypanblau on 

 heartwater of sheep and goats and South African redwater of cattle are stated 

 to be under way. 



Infectious jaundice due to Piroplasma commune, J. McI. Phillips and E. F. 

 McCamphell (Centbl. Bakt. [etc.}, 1. AM., Orig., 7,7 (1908), A'o. 5, pp. 592-608, 

 pi. 1, figs. Ji, charts 2). — This is a preliminary report of an epizootic of dogs at 

 Columbus, Ohio, which is similar to that caused by P. canis. 



By inoculation the disease was produced in guinea pigs and cats as well as 

 dogs, but not in the horse, cow, rabbit, or rat. Although the disease is ^•ery 

 virulent for guinea pigs when inoculated into the peritoneal cavity or sub- 

 cutaneously, it is not in the least contagious. By means of Wright's modifica- 

 tion of Jenner's stain, applied for a long period of time, the authors were able 

 to demonstrate protozoan parasites within the erythrocytes of blood from 

 guinea pigs. These organisms were found to be similar to P. canis, but since 

 they differ from it in being pathogenic in other hosts than the dog, the name 

 P. commune has been applied. "Two regular forms of the parasite have been 

 noted so far, a round and a piroform or pear shape. The size varies in the 

 round forms, which are more abundant, from 0.5 to 1.5 microns in diameter 

 and in the pear shaped forms from 1.5 to 2 microns in width at the widest 

 place and from 2 to 3 microns in length. There is great pleomorphism among 

 thfe piroplasmata as in P, amis and /'. bigeminiim..'' 



