88 EXPEEIMENT STATION RECORD. 



The results obtained from Negri's method were always positive in cases where 

 the corpuscles were found and since the method seems to be perfectly reliable 

 to that extent it is considered useless to sacrifice animal life in making inocu- 

 lations when the corpuscles are found. A detailed tabular statement is pre- 

 sented of the various animals examined and of the ttndings of Negri's bodies 

 and lesions in the Gasserian ganglia. 



The significance of Negri's corpuscles in the diagnosis of rabies, W. 

 Ernst (Moiiatsli. Prakt. Tierhcilk.. 17 (lOOG). ^'o. !)-lU, pp. 453--',66, figs. 3).— 

 The author made a careful study of the nature and occurrence of Negri's cor- 

 puscles in animals affected with rabies. As a result of these investigations it 

 was found that in 9G to 99 per cent of the cases of rabies in which clinical 

 symptoms have appeared, intracellular structures are found in the central 

 nervous system which do not api)ear in healthy animals or in the case of any 

 other disease. The microscopic recognition of rabies by this means is possible 

 oven when, on account of decomposition of the material, no help could be 

 expected from inoculation tests. In all cases where Negri's corpuscles are 

 found the diagnosis of rabies is considered perfectly reliable and inoculation 

 tests may be omitted. The diagnosis may be made with a certainty within 3 

 to 4 hdurs by means of an embedding method calling for the use of acetone and 

 I'arallin. It still remains doubtful whether Negri's corpuscles are a develop- 

 mental stage of the rabies organism or a i)roduct of cell I'eaction to the disease. 



Negri's corpuscles in rabies, N. Ball (.lrc/(. ^'et. Xaiik [l^t. Pctersl).], 3(! 

 (191)6). .Yo. 3. pp. 1.53-170, figs. 2). — The literature relating to this subject is 

 critically discussed in connection with a short bibliography. The author pre- 

 sents in a tabular form the results obtained by various investigators in an 

 examination of the brain tissue of rabid animals for the presence of Negri's 

 corpuscles. As a result of the author's study, it is concluded that approxi- 

 mately 9G.5 per cent of animals affected with rabies show peculiar structures 

 known as Negri's corpuscles in the nerve cells, particularly in Ammon's horn. 

 In healthy animals or in animals affected with any other disease than rabies, 

 Negri's corpuscles are not to be found in the nerve cells. These bodies, there- 

 fore, constitute an excellent means of diagnosis which may be accomplished 

 within 5 to 7 hours after the post-mortem examination of the animal in ques- 

 tion. The absence of Negri's corpuscles in the nerve cells of animals suspected 

 of rabies does not exclude the possibility of rabies being present. 



The toxin produced by Aspergillus funiigatus, E. Bodin and L. Gautier 

 (Ann. lust. Pasteur. 20 (190G), No. 3. pp. 209-224) .—From the study of this 

 fungus in cultures and in experimental animals it was found that Aspergillus 

 funiigatus produces a toxin which ma.v be rightfully compared with the toxins 

 of bacteria. For the formation of this toxin in cultures it is necessary to have 

 a mixture of protein, especiall.v of the peptone t.vpe, and some carbohydrate, 

 especially glucose, saccharose, maltose, or dextrin. The reaction of the toxin 

 must be either neutral or alkaline. The effects of the toxin are chiefly observed 

 in the nervous system and are produced more or less rapidly by the method of 

 inoculation. The s,vmptoms of poisoning from the toxin are muscular con- 

 vulsions resembling tetanus and leading to death within a few hours if the ani- 

 mal does not recover. The rabbit and dog are very susceptible to the toxin, 

 while the guinea pig, cat, mouse, and white rat are more refractor,v. The dog 

 and cat are naturall.v immune to the spores of A. fumigatus, but are quite sus- 

 (■e])t!ble to the toxin pntduced by the fungus. 



Chicken pox: The forms of chicken pox and their relation to true pox 

 and their micro-organisms. Keischauer (Centbl. Bakt. [etc.], 1. AM., Orig., 

 .',0 {1900), Nos. 3, pp. 356-361; Jf, pp. ^7-M79; 5, trp. 653-683, pis. 2).— The 



