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of the force; these fibrillae increasing in length iuid (Ua- 

 meter. The fibrillar are located in the (lireclion ot the line 

 of forces of the clot. If the clot is suspended in a moist 

 chamber, the fibrillar will liave the direction of the gravity. 



Bj^ the histological examination of the artificial fibrous 

 tissue, it was shown, that there was no difference between 

 those and the wavy bundles of fibrous tissue in vivo. They 

 were stained in exactly the same way by Mai lory's con- 

 nective tissue stain. The illustrations in the papers of 

 Bait sell are beautiful and convince us (hat liie fibrous 

 tissue artificially produced is identical with that in vivo. 



It is of course well known that the supporting structures 

 of the organism, are laid down in exact correspondance 

 to the definite stresses; it is therefore concluded that tiic 

 various mechanical factors are introduced during develop- 

 ment, such as has been described by B a i t s e 1 1 to he the 

 case with the plasma clot. 



The other point of view as to the origin of the fibrous 

 tissue fibrillar, the intracellular origin, which standpoint 

 is taken from experiments on tissue in vitro, is represented 

 by M. B. Lewis ^39) Yhe fibroblasts were cultivated ac- 

 cording to M. B. Lewis, in fibrin-free media, and on 

 the coverglass as support for the cells. The cultures of 

 fibroblasts grow then in a way similar to endothelium and 

 by special preparation (nitrate of silver and vapour of 

 osmic acid) demonstrate the connective tissue fibrilla?. M. B. 

 Lewis was able to observe mitochondria in the finest 

 fibrillae, a fact which speaks clearly for the cellular origin 

 of the fibrils observed by L e w i s. Probably the fibrillse 

 of Baits ell and the fibrillae of Lewis are two different 

 things, which both occur in vivo. 



I myself am most inclined to assume that the B a i t s e 1 1 

 theory is the most correct. Both kinds of fibrilhr do exist 

 in the body. Those of Lewis are probably the syndes- 

 motic fibrillic connecting the tissue cells in general and 

 which play the important role in the function of the tissues, 



