2(>() 



III all tbi' c'liltiii'cs examined, ol' luimaii sarcoiiiala. chicken 

 sarconia as wi-ll as ol' I" I e \ n e r - .1 o h 1 i n jf ral car- 

 cinoma, il was ()1)si'1"\cm1 that Ihe cells wi'i'c wandeiMiiy 

 in and amoni; olluT cells. eslal)lisliini.f |)ei1\'cl imilion wiili 

 Ihem. whereupon they sei)arale(l af^ain. wanderin<T h) othei" 

 cells, uniting and separalinfj and so on. In a Tew cases 

 il was aclually ohser\'ed. how a pi'i-lecl amaIf»amalion ol" 

 Iwo cells look place, whereupon lhe\' sepai'aled and each 

 cell dividtnl and llu' 1 new indi\iduals weri' movini* around 

 under lively ameboid movemenl. 



0/^ 



12 3 4 5 



Fig. 70. 

 Represent a cell belonging to the medium sized cell type, trying to pene- 

 trate into a much larger cell belonging to the fibroblastic type of cell. 



It is loo I'ai-lv now lo say anything al)oul the significance 

 of the process of amalgamation of malignant cells with 

 regard to cell division. Compared with the observations 

 made on normal fibroblasts, where no cell division of scat- 

 tered and isolated individuals was seen, il must be said 

 that what is described here is a general occurrence for 

 the sarcoma cells. In almost all the examined cultures of 

 sarcoma cells, which were isolated, cell divisions could 

 be observed. That this is Irui'. 1 foimd by trying to 

 contaminate a piece of nornial muscular tissue with only 

 one sarcoma cell and I was within 18 hours able la 

 obtain a bii« culture of sarcoma cells. 



