DISCUSSION 



Chairman: Dr. Warren O. Nelson 



Dr. Vaughn Cruchlow: We have followed the work of Donovan and van der Werff ten 

 Bosch, reviewed this morning by Professor Harris, with a great deal of interest. In 

 collaboration with Miss Elwers, we have undertaken a series of experiments in the 

 rat to examine the anatomic specificity of lesions that hasten puberty, and to determine 



Fig. 1. Projections of effective hypothalamic lesions on a midsagittal diagram of the 

 diencephalon. Abbreviations used: AH, anterior hypothalamic area; ARC, arcuate nucleus; 

 CC, corpus callosum; DM, dorso-medial nucleus; M, massa intermedia; OCH, optic 

 chiasm; MB, mammillary body; PV, paraventricular nucleus; VM, ventromedial nucleus. 



whether the amygdaloid complex might be implicated in the neural mechanisms 

 which are postulated to inhibit gonadotropin secretion. A more complete account of 

 this work was published recently (I). 



The methods used were similar to those outlined by Bogdanove and Schoen (2) who 

 also observed the puberty-inducing effects of anterior hypothalamic lesions. All 



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