88 



Charles H. Sawyer and M. Kawakami 



-//- 



ESTROGEN-PRIMED 

 OVARIECTOMIZEO 

 I 1999 



K 



V 



BEHAVIOR ATTACKED ?^ 

 MATED WITH .^ -- 

 EEG AFTERREACTION ^ 

 COITUS 

 VAGINAL STIM 

 THRESHOLD 

 (STIM. VMH SEC) 



8 

 TIME 



Q 24 28 

 HOURS AFTER 



46 SO 54 66 



FIRST PROGESTERONE 



/ 



5V,0.IV,0.IV -, 15V 

 0.25V 0025V 5V 



Fig. 7. Diphasic effect of progesterone on thresholds of EEG arousal (curve) and EEG 



afterreaction (tabulated below), and prolonged elevation of thresholds following second 



injection of progesterone. From Kawakami and Sawyer (43). 



OVARIECTOMIZEO ESTROGEN-PRIMED? 



• EEG AROUSAL 



* EEG AFTERREACTION 

 A NO AFTERREACTION 



■A A. 



»^ 



•^./" 



-a 4-T » 





3 4 5 



HOURS AFTER 



6 7 8 



PROGESTERONE 



< •- > 



I HIPP. 

 HYPERACT. 



□ SPINDLE 

 BURSTS 



D' 



V C E VC E EC 



V-VAGINAL STIM., C-COITUS. E 



E V E CEV 



■ELECTRIC STIM. 



ICOITUS 

 iREFUSEO 



Fig. 8. Thresholds and EEG afterreaction data during the first 10 hr after progesterone 

 treatment of an ovariecloniizcd estrogen-primed rabbit. Open triangles represent 

 unsuccessful attempts to elicit the EEG afterreaction. From Kawakami and Sawyer (43). 



