Discussions 121 



on ovarian weight increase in immature female rats, and specific LH content using the 

 Weaver-Finch test (Segal, S. J. and D. C. Johnson, Arch. d'Anat. Micros, et Morphol. 

 Exper. 48 bis, 261-274. 1959). 



The assays show that, like the normal male, the anovulatory female pituitary is 

 richer in gonadotropins, both total and specific LH content, than the normal female. 

 (Table 1.) 



In the same article {ibid.) we have reported on the mating reactions of anovulatory 

 females (Table 2). About 30% accept males. Some (about 10% of the total group 

 tested) will respond to the mating by spontaneous ovulation. The total results of 

 these studies indicate that the androgens administered post-natally have a direct 

 inductive effect on the neural centers controlling gonadotropin release and the 

 extent of this effect can vary among the treated animals. In some cases a partial 

 induction of the total gonadotropin-releasing neural mechanism(s) results from the 

 androgen treatment. Varying degrees of effect could be distinguished. 



