196 



Carl A. Gemzell 



with advanced hypogonadism and a young woman who was recently operated 

 upon due to a chromophobe adenoma. The other patients tested had a 



HCG(6000lu/(l) 



FSH(lCmg/d) 



(Ettront (>jg/48hrs) 



CIstrodiol-17p(pg/4Bhrs 



astriol(>jg/«8hrs) 



Prtgnonediol (mg/48 hrs) 



17-OHCS {mg/;8hrs) 



17-KS(fng/48hrs) 



Endomatriol Activitjr 

 I A A 



J i 



?5/ 30/ 5/ 10/ 15/ 



/l1 /ll /12 /l2 /12 



Fig. 1. Urinary excretion of estrone, estradiol- 17(5, estriol, pregnanediol, 17-hydroxy- 

 corticosteroids and 17-ketosteroids before and following the administration of human 

 chorionic gonadotropin (HCG) and — two and a half months later — of human pituitary 

 follicle-stimulatin ghormone (FSH). Endometrial activity in biopsies: A = atrophic 



endometrium. 



long-lasting amenorrhea with atrophic or weakly proliferative endometrial 

 activity indicating little or no ovarian function. 



