Induction of Ovulation in the Human by Human Pituitary Gonadotropin 197 



Following the administration of 10 mg of human pituitary FSH over a 

 10-day period a polycystic enlargement of the ovaries was found in 27 out 



800. 



600. 



400. 



200. 



Pregnanediol (mg/A8hi-s.) 



'"L 



20_|17-OHCS (mg/AShrs) 

 10 



20.17-KS (mg/i8hrs) 

 10 



Endometrial Activity 



ES 



1959 10/2 



20/2 28/2 5/3 10/3 



Gemzell 29/1-60 



Fig. 2. Urinary excretion of estrogen, pregnanediol, 17-hydroxycorticosteroids and 



1 7-ketosteroids before and following the administration of FSH and HCG. Endometrial 



activity : P — proliferative, ES = early secretory reaction. 



of 40 women, an increase in estrogen excretion in 16 and an increase in 

 pregnanediol excretion in 4 out of 30 women. Of 27 women with atrophic 

 endometrium before the treatment 16 responded with proliferative activity, 



