Induction of Ovulation in the Human by Human Pituitary Gonadotropin 199 



She was treated with HCG alone, with FSH followed by HCG and with 

 FSH and HCG simultaneously. HCG alone had no effect. FSH caused a 

 marked increase in the urinary excretion of estrogen, evident as early as 

 after 5 days of treatment. The urinary excretion of estrogen reached a very 



500. 



HCG(6 000LU/dJ 



mm , 



Estrone {>ig/48hrs.) 



Case S L Age 2iyear. 



FSH (lOmg/d) HCG(6000LU/d) 



mrnmrnmni 



Estradiol-17/3t>jg/4ehrsJ 



1 



Endometriol Activity 



15/4 



25/, 2C/8 



5/9 10/g 



Gemzcll 9/2-60 



Fig. 3. Urinary excretion of estrogen, pregnanediol, 1 7-corticosteroids and 1 7-ketosteroid& 

 before and after the administration of HCG and FSH. (O) = day of ovulation. 



high level, almost 5 mg per 48 hr. The ovaries increased in size during the 

 same time, attaining a diameter of about 5 cm. When HCG was administered, 

 4 days after the last injection of FSH, an ovulation took place within 24 hr 

 as indicated by the sharp rise in pregnanediol excretion and the secretory 

 14 



