200 



Carl A. Gemzell 



reaction of the endometrium. During the administration of HCG the ovaries 

 increased further in size and reached the umbilicus. By a culdoscopy a large 

 folHcular cyst was evacuated and 750 ml of follicular fluid was collected and 

 analyzed for estrogen. The fluid contained all three estrogens — estrone, 



Case M U Ag* 31 year 



?9/12 



5/1 



10/1 



21/2 



10/3 



Fig. 4. Urinary excretion of estrogen, pregnanediol, 17-corticosteroids and 1 7-ketosteroids 

 before and following the administration of HCG and FSH. 



estradiol- 17j8 and estriol. Following the withdrawal of the follicular fluid 

 the urinary excretion of pregnanediol decreased from 140 mg to 60 mg per 

 48 hr. When FSH and HCG were administered together an ovulation 

 occurred on the 6th day of treatment as indicated by the rise in pregnanediol 



