Induction of Ovulation in the Human by Human Pituitary Gonadotropin 205 



Human pituitary FSH was administered in order to prove that her ovaries 

 responded. A schedule was prepared for induction of ovulation at certain 

 points of time. The first attempt was a failure but the second one was success- 

 ful. A rise in body temperature occurred at the time when ovulation was 



Cose EG Age 26year 

 HCG (6000IU/d) FSH (lOmg/d) 



ITHT] . Uliilliii 



Estrone (pg/iShrs) 



400 

 300 

 200 

 100 . 



200 ■ Estradiol-17/3(pgM8hrs) 

 100 . 



Endometnol Activity 

 P S 



J_ 



\ 15/^ 20/, , 10/5 15/5 20/5 26/5 



Fig. 9. Urinary excretion of estrogen, pregnanediol, 17-corticosteroids and 1 7-ketosteroids 

 before and following the administration of HCG and FSH. 



predicted to occur. When 2 weeks later no menstrual period appeared and 

 the temperature was still elevated a pregnancy was suspected. Two weeks 

 later positive pregnancy tests confirmed the diagnosis. The patient delivered 

 double ovum twins 265 days later (Fig. 11). 



Unfortunately, only in a few cases was it possible to examine the ovaries 

 following treatment with human pituitary FSH and HCG. Following FSH 

 alone the ovaries showed a great number of follicular cysts of various sizes. 



