208 



Carl A. Gemzell 



correlated with 5 corpora lutea. It seems also important that HCG was 

 administered during a relatively short period of time, for HCG caused further 

 enlargement of these ovaries which were stimulated by FSH. 



Table 2. Inducing Ovulation by FSH ( + LH) in Amenorrheic Women 

 WITH Various Endometrial Activity 



FSHtLH) 



♦ Estrogens 



FSH(LH) 



FSH(LH) 



t Estrogens 



Fig. 12. The mechanism of ovulation in amenorrheic women with atrophic endometrium 

 (1 and 2) and in those with proliferative endometrial activity (3). 



The FSH preparation used in this study caused an increase in the produc- 

 tion and release of estrogen even in a patient without a pituitary. A similar 

 increase following the administration of a highly-purified preparation of 

 FSH has not been observed in hypophysectomized animals. Only after small 



