Inhibition of Ovulation in the Human 



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Raymond Borno, and Vergniaud Pean in Haiti. Dr. Celso-Ramon Garcia, 

 who largely planned the clinical aspects of these projects, makes periodic 

 visits to Puerto Rico and Haiti for consultation, collection of biopsy material, 

 and examination of patients. 



The regimen adopted in the island projects entails cyclic medication with 

 10 mg per day of Enovid from cycle-days 5 through 24, inclusive, i.e. a total 

 of 20 pills a cycle, or one less pill than in the schedule first followed in the 

 local cases (v.s.). 



As of November, 1958, 830 subjects had participated in the experiment 

 (Table 6). Of this number, there were 519 who were still using the medication. 

 In all, there were 8133 cycles of experience, the sum total of which added up 



Table 7. Fertility Control with Enovid: Mean Age of Subjects and Pregnancy 

 Rates Before and During Medication in the Four Projects 



to 635 woman-years. In Table 7 are seen the pregnancy rates before and during 

 medication in the four projects. Whereas the mean pregnancy rate before 

 treatment had been 61.2 per 100 woman-years, it decreased during medication 

 to 2.7, representing "a 96 per cent reduction in the pre-medication rate, and in 

 terms of years of exposure to the chances of conception (i.e., eliminating 

 pregnancy times in pre-medication years) a 98.9 per cent reduction in fertility" 

 (30). It should be noted that the frequency of coitus remained essentially 

 the same during medication as it had been prior to treatment (Table 8). 



With the most recent survey, as of November, 1959, the number of cycles 

 had increased to more than 12,000; and the total number of women treated 

 to about 1200. We think we have a fairly dependable picture of what this 

 material will do. The pregnancy rates, as of November, 1959, are shown in 

 Table 9. 



Here we see more than 10,000 cycles during which no tablets were missed. 

 Within this group, there is one questionable case of a pregnancy in a social 



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