238 



John Rock 



at 10 )u in thickness and every twentieth section was mounted and stained 

 for study. Most of the specimens suppHed from 10 to 25 such selected sections. 

 More were available in the control group than could be obtained from 

 biopsy material. 



J_ 



PRIMORDIAL FOLLICLE COUNTS IN OVARIES 

 UNTREATED AND TREATED WITH ENOVID 

 10 mgyd, D5-25/Cycle 



SEPT 1958 



I I UNTREATED 



P=^ TREATEO 



NO or 



NO OF OVARIES 



FOLLICLES mn CORTEX 



Fig. 4. Effect of Enovid (and Norlutin) on the number of primordial ovarian follicles in 

 women of different age groups. 



The stained slides were then projected on a screen for accurate measure- 

 ment of curvilinear distances along the ovarian cortex, and the number of 

 primordial follicles per millimeter of cortex was computed. The values for the 

 untreated and the treated specimens were then compared. Statistically, there 

 was no significant difference between untreated and treated ovaries in the 

 number of primordial follicles present. Even in one woman who had received 

 medication for 20 cycles, the number of normal primordial follicles was not 

 less than the control value. 



