80 EXPERIMENT STATION RECORD. 



relating to quarantine and the control of disease (pp. 149-158) ; quarantine 

 regulations (pp. 159-183) ; an address on Bovine Tuberculosis (pp. 335-337) by 

 J. G. Rutherford; Further Report on the Dourine of Western Canada, part I 

 (pp. 465-472) by E. A. Watson; and a paper on Trypanosomes Found in 

 Canadian Mammals (pp. 473-476) by E. A. Watson and S. Hadwen, previously 

 noted from another source (E. S. R., 27, p. 81). 



The determination of the minimal lethal dose of various toxic substances 

 and its relationship to the body weight in warm-blooded animals, together 

 with considerations bearing on the dosage of drugs, G. Dbeyee and E. W. A. 

 Walker {Proc. Roy. Soc. [London], Set: B, 87 {19U), No. B 595, pp. 319-330).— 

 " In warm-blooded animals of the same species but of different weights dosage 

 must be calculated in relation to the body surface. This result agrees with the 

 conclusion already reached by Moore [E. S. R., 21, p. 581] though on different 

 grounds. This statement is to be explained on the ground that the concentra- 

 tion in the plasma of any given substance administered is dependent on the 

 volume of the circulating blood, which is itself proportional to the body sur- 

 face in any given species of animal. It follows that in the accurate measure- 

 ment and standardization of toxic substances and antitoxins it will now be 

 possible to make use of animals of different weights within a given species 

 instead of using only animals of an arbitrarily selected weight, as has hitherto 

 been necessary. Results in dosage calculated from one species of animal can 

 not directly be applied to another species merely by taking surface into due con- 

 sideration, since tolerance and intolerance are specific characters which are 

 shown to be in many cases independent of the size of the species concerned." 



A bibliography of 25 references is appended. 



A note on nitrous oxid as an anesthetic in animal experimentation, D. H. 

 DoLLEY {Jour. Expt. Med., 19 (WU), No. 4, pp. 312-315, fig. 1).—" Nitrous oxid, 

 administered by means of the Gatch apparatus, as a preliminary anesthetic to 

 ether has been found to be superior for the dog in rapidity of action, in promo- 

 tion of ease of handling, and in absence of disorder ; the anesthesia may be 

 maintained solely by nitrous oxid in combination with oxygen ; it is economical ; 

 and its use is instructive to students from closer imitation of current surgical 

 methods." 



Poisoning by castor seeds (Ricinus), G. D. Lander (Vet. Rec, 26 {1914), 

 No. ISJfl, pp. 614-618) .—Attention is called to the fact that in spite of the well- 

 known dangerous character of the castor oil seed {Ricinus communis) it is not 

 uncommonly encountered in horse mixtures and in cakes. 



Critical and experimental data in regard to the formation of leukins, R. 

 Schneider {Arch. Hyg., 15 {1912), No. 4-5, pp. 161-188; abs. in Ztschr. 

 Immunitutsf. u. Expt. Ther., II, Ref., 5 {1912), No. 9, p. i57).— This is a dis- 

 cussion of the work of Pettersson and his coworkers. The endolysins obtained 

 by Pettersson are considered secretory products which correspond to the leukins, 

 and the results obtained by Pettersson do not discredit those reported by the 

 author because other technique was used. 



Digesting leucocytes in a 5 per cent serum-sodium chlorid (0.85 per cent 

 NaCl solution) at body temperature is deemed the best method for obtaining 

 bactericidal substances from the guinea pig. Serum is added for the purpose of 

 stimulating the leucocytes to yield the bactericidal substances. The bacteri- 

 cidal substances can only be obtained from dead leucocytes when the cell struc- 

 ture has been thoroughly disintegrated. 



Bacteria, M. Schottelius, trans, by H. Geoghegan {London, 1912, 2. ed., 

 pp. xn+324, pis. 10, figs. 33). — This small book contains chapters as follows: 

 Position of bacteria in the scheme of nature and in regard to other forms of 



