284 EXPERIMENT STATION RECORD. 



"As a result of the expei'iments the vohiuio of virns used for iujectious ui 

 the process of hyperimmunization has beeu further reduced to 2.5 cc. per pound 

 body weight in the case of plains cattle. For hill bulls and buffaloes a volume 

 at the rate of 3 cc. per pound body weight is now used. Further, it has been 

 found imnecessary to increase the volume of virus in each successive injection, 

 as was generally practiced. Animals reinjected several times with the same 

 volimie continue to produce a serum of value equal to that obtained after the 

 first injection." 



Some further contributions in reg'ard to the chemotherapeutic action of 

 antimony preparations for spirochete and trypanosome diseases, P. Uhlen- 

 HUTH and G. Hugel (Deut. Med. Wchnschr., 39 (1913), No. 50, pp. 2455-2457).— 

 Among a number of organic antimony preparations the following were found to 

 be active against spirillosis in fowls: The sodium salts of acetyl-p-aninophenyl- 

 antimonic acid, benzolsulphon-p-aminophenylantimonic acid, p-urethanophenyl- 

 antimonic acid, m-amino-p-urethanophenylantimonic acid, mi m^iamino-p- 

 o^y-Pl-chlorarsenostibiobenzoldihyd^ochlorid, and nii m^-diamino-p-oxyarsenosti- 

 biobenzol. The first three named substances also gave good I'esults in curative 

 tests for rabbit syphilis, and the first two and last two, as well as p-anisylanti- 

 monic acid, in experimental dourine in mice. Acetyl-p-aminopheuylantimonic 

 acid was also effective in mouse nagana. 



In addition to these metallo-organic compounds experimental tests were made 

 with stibium arsenicosum, a colloid preparation with antimony hydroxid. 

 Sb(0H)3. 



The inorganic ])reparntions were of no value in fowl spirillosis. 



The present status of our knowledge of the trombidiases of man and 

 domestic animals and a new trombidiasis of the goat, B. Galli-Valerio 

 (Centbl. Bald, [cic], 1. Abt., Rcf., 56 (1913), No. 5-6, pp. 129-145. figs. 4).— 

 The author states that he has been unable to find any report of the occurrence 

 of this disease in the goat prior to his study of a very grave affection among 

 goats in the Valtelline region, which is here reported upon. The parasite con- 

 cerned was Microtromhidmm pusillum, a species which the author had pre- 

 viously found in the same region on the dog. 



About the formation of protein and mucin by tubercle bacilli. F. Welemin- 

 SKY (Berlin. Klin. Wchnschr., /,.9 (1912). No. 28, pp. 1320-1322; abs. in Chem. 

 ZentU., 1912, II. No. 16, p. 1386). — In cultures of the tubercle bacillus, mucin 

 was repeatedly detected; coagulable albumin was also noted. The mucin does 

 not seem to originate from the dead tubercle bacilli and must consequently be 

 a product of metabolism. The methods used which predispose to mucin forma- 

 tion diminish the virulence of the organism. 



A new contribution to the pathology of tuberculosis infection, A. Cal- 

 METTE and C. GuliRiN (Compt. Rend. Acnd. Sci. [Parl^], 156 (1913). No. 1, pp. 

 34-37; abs. in Rev. G^n. MM. V^t., 21 (1913), No. 246, pp. 323-325) .—Some 

 authors believe that tuberculosis in cattle, especially the isulmonary form, is 

 due to the ingestion of tubercle bacilli, and others think it caused by the inhala- 

 tion of tuberculous particles. In order to determine which of the above theo- 

 ries is correct, some experimental tests with cows were conducted. Five adult 

 cows affected with pulmonary tuberculosis were placed in a barn and faced 

 toward the wall. The excrement of all of these animals was infectious for 

 rabbits. 



About 3 meters behind these animals ten 10-months-old heifers were quar- 

 tered but separated from the other animals by a wooden barrier. The barn 

 was so arranged that the urine flowing from the tuberculous cattle would run 

 into the pens of the healthy animals and cnnseqneiilly soil their litter. The 

 cattle were left together in this building for 11 months and then tested with 



