480 EXPERIMENT STATIOISr RECORD. 



was found that the protective value of serum is iu direct proportion to the 

 amount of opsonin present. 



Keport on foot-and-mouth disease in Ireland in the year 1912 (Dept. Agr. 

 and Tech. Instr. Ireland, Rpt. Foot-and-mouth Disease, 1912, pp. 74, pis. 29; 

 Vet. Jour., 70 (1914), Nos. 463, pp. 6-23, figs. 6; 464, PP- 57-73, figs. 3).— This is 

 a detailed report upon the outbreaks of foot-and-mouth disease iu Ireland in 

 1912 and measures taken for its eradication, a brief account of which from 

 another source has been previously noted (E. S. R., 29, p. 677). 



About a new serodiagnostic method, W. Pfeileb and G. Webee (Berlin. 

 Tierarztl. Wchnschr., 29 (1913), No. 25, pp. 449-452).— It has been found that 

 the conglutination method (E. S. R., 28, p. 478) is on a par with the comple- 

 ment fixation method for diagnosing glanders. In fact, in some cases of 

 glandered horses which were not detected by the complement fixation method 

 the condition was diagnosed by it. It also has the advantage that (1) it is 

 more easily conducted, as it does not require a specially prepared amboceptor. 

 (2) guinea pig serum is replaced by horse serum, which is more easily ob- 

 tainable and must not be standardized, and (3) the test can be conducted 

 without the use of an incubator. In this work it was found also that neither 

 the presence of complement nor bovine serum containing conglutinins is neces- 

 sary for the conglutination test. 



Theoretically si)eaking. horse serum contains a substance capable of con- 

 glutinating glandei's bacilli, and which is consequently similar to Bordet's sub- 

 stance which he terms " colloide de boeuf." It is believed that many of the 

 agglutinins which are present under normal conditions are not agglutinins at 

 all, and, in fact, it seems reasonable to believe that another substance is present 

 whose function it is to combat infection. It was found to be absent in the sera 

 of infecte<l animals and its action is especially noted when the sera of normal 

 animals are heated to 5G° C. 



The effect of quinin on rabbits inoculated with rabies, L. Fbothingham 

 and J. IlALLiDAY (Jour. Med. Research, 30 (1914), ^o. 3, pp. 275-280).— In these 

 exi>ei-iments neither quinin bisulphate nor quinin and urea hydrochlorid, dis- 

 solved in w;iter and administered subcutaneously, had any curative effect upon 

 rabbits which showed symptoms of rabies after intracerebral, subdural, and 

 intramuscular inoculation with street virus. The injections caused a local re- 

 action with necrosis and. in the control rabbits, subsequent sloughing. 



The quinin treatment of rabies, J. G. Cxtmming (Jour. Infect. Diseases, 

 15 (1914), No. 1, pp. 205-208). — " Inasmuch as the quinin failed as a preventive 

 measure against extremely small doses of virus in actual tests, can it not rea- 

 sonably be assumed that this method of treatment is of no curative value in 

 cases of hydrojihobia manifesting symptoms In which the amount of virus would 

 be many tliousand times greater?" 



The duration of passive immunity against tetanus toxin, E. H. Ruedigeb 

 (Philippine Jour. Nc/., ticct. B, 8 (1913), No. 2, pp. 139-142; abs. in Berlin. 

 Tierarztl. Wchnschr., 29 (1913), No. 39, p. 696). — The subcutaneous injection of 

 1.500 luiits of (horse) tetanus antitoxin produces a passive immunity in horses 

 in about 6 to 8 weeks. If normal horse serum is repeatedly injected into guinea 

 pigs and the injection followed with antitoxin, the immunity produced in these 

 animals is greater than in animals which have received no horse serum. 



New observations upon the trombidiasis of goats and its transmission to 

 man, B. Galli-Valeeio (Ccntbl. Bald, [cfc], 1. Aht., Orig., 72 (1914), No. 6-7, 

 pp. 488-490, figs. 2).— In this paper (E. S. R., 31, p. 284) the author reports 

 that the larvae of Microtrombidium pusillum, which cause the trombidiasis of 

 goats iu Valtelline, also cause a cutaneous eruption in man which is accom- 

 panied by violent itching. 



