482 EXPERIMENT STATION RECORD. 



most of its inliibiting properties, retains its agglutinins and sensibiiisins. and 

 these can be more easily detected. 



The reciprocal affinity of tuberculins prepared from tubercle bacilli ob- 

 tained from man, bird, fish, and Rabinowitsch's bacillus, E. Cabapelle 

 (Biochim, e Terapia Sper., 3 {1912), pp. 351-361 ; abs. in Ztschr. Immunitdtsf. 

 u. Expt. Ther., II, Ref., 6 {1912), No. 11, pp. 814, 815).— It was the object of 

 this work to determine whether the various tuberculins contain the same prin- 

 ciple, and if so, whether this principle produces the same antibody. After de- 

 termining the minimal fatal dose of each of the tuberculins for guinea pigs, 

 animals were immunized with increasing doses. The sera of the animals were 

 then tested for their content of opsonins, agglutinins, complement fixing sub- 

 stances, and meiostagmins. 



The tuberculin prepared from the acid-fast strain of Rabinowitsch's bacillus 

 had a different behavior toward the various biological reactions than any of the 

 other preparations, i. e., Wright's positive and negative phase did not appear. 

 The human, avian, and fish tuberculins produced amboceptors and agglutinins 

 in the serum which behaved alike tow;ird the opposite strains, and consequently 

 it is concluded that all of the organisms produced the same antibody. Evi- 

 dently a strong affinity exists between the various tuberculins. Meiostagmins 

 were not noted in the blood of the various guinea pigs. 



Guinea pigs infected with the organism of human tubercle bacilli, followed by 

 treatment with small doses of tuberculin, died 25 days later than the controls. 

 If tuberculin is given first, the conditions are reversed. 



The production of passive hypersensitiveness to tuberculin, C. R. Austrian 

 and H. Fried {13ul. Johns Hopkins Hasp., 24 {1913), No. 211, pp. 280-282).— 

 The results confirm the established fact that free seusibilisin can not be demon- 

 strated in the bloo<l of most individuals affected with pulmonary tuberculosis. 

 The anaphylactic nature of the tuberculin reaction was shown. 



Proposal for an extension of the measures for combating mammary gland 

 tuberculosis in bovines in Sweden, A. M. Bekgman {Ztschr. Fleisch u. Milch- 

 hyg., 23 {1913), No. 10, pp. 211-219) .—After showing that tuberculosis of the 

 udder is still on the iucrea.se in Sweden and Denmark, various recommendations 

 are made with a view of detecting this condition at an early date. It is con- 

 sidered essential that dairy animals be examined at least four times a year by 

 competent veterinarians. 



[Periods of high temperature in cattle imported into Guam], J. B. Thomp- 

 son {Uuain 8ta. Rpt. 1913, pp. 9-11, figs. 4}- — 'J^iie author presents temperature 

 charts which show the periods of high temperature that have occurred in im- 

 ported cattle. In some instances these fever periods have not been marked by 

 excessively high temi^erature and have been of comparatively short duration. 

 On the other hand, cases have been dealt with in which the temperatures have 

 risen above 107° F.. and the period prolonged for more than a week. 



Experimental bovine mastitis produced with hemolytic streptococci of 

 human origin, D. J. Davis and J. A. Capps {Jour. Infect. Diseases, 15 {1914), 

 No. 1, pp. 135-140). — "Hemolytic streptococci of human origin may cause mas- 

 titis, lasting for several weeks in cows. This time roughly corresponds to the 

 duration of milk-borne epidemics. The streptococci may gain entrance through 

 an abraded or injured surface of the teat. It appears possible, therefore, for 

 mastitis in cows to be produced by an infection from the milker whose hands 

 are contaminated perhaps from a sore throat. Mastitis results promptly when 

 the cocci are injected directly into the udder by means of a catheter. The 

 niiistitis may exist without physical evidence. A calved bag may not occur, 

 though pus and streptococci in large numbers are being secreted in the milk. 



