880 EXPEEIMENT STATION RECORD. 



in pigs, and lip and leg ulceration in sheep. These diseases are said to have 

 caused widespread loss in Colorado during the past ten years. 



In regard to the etiolog'y of rabies, F. Peoeschek {Berlin. Klin. Wchnsehr., 

 50 (1913), No. 14, pp. 633-636, figs. 17; abs. in Ztschr. Immunitdtsf. u. Expt. 

 Ther., II, Ref., 7 {1913), No. 5, p. 228).— With the aid of the antiformin test a 

 microscopically visible organism was noted in the brain of rabid animals and 

 man. 



The methods for protectively vaccinating against rabies, N. Pokschis- 

 CHEWSKY {Ztschr. Eyg. u. Infektionskrank., 76 {1914), No. 3, pp. 453-^68). — 

 After reviewing the work of others, including that of Miessner, Kliem, and 

 Kapfberger, and Pfeiler and Kapfberger (E. S. R., 30, pp. 281, 282), the results 

 of the author's work, which was done for the purpose of determining whether 

 it was possible by the original Pasteur method and the intraperitoneal injection 

 of fresh brain substance from i^assage rabbits to immunize negatively experi- 

 mental animals, chiefly dogs, are reported. 



The results show that the original and the modified Pasteur methods are not 

 efficacious for immunizing dogs against a subdural or Intramuscular infection 

 with a rabies virus. 



In testing experimental animals as regards immunization it is necessary to 

 use satisfactoi*y methods of infection such as the subdural and intramuscular 

 methods with street virus. The intraocular method is not reliable and uncer- 

 tain results are always obtained by subcutaneous application and by the bite 

 of a rabid animal. The intraperitoneal method with large doses of fixed virus 

 gave a certain active immunity in dogs and rabbits. The immunity was tested 

 with an intramuscular injection of street virus. Only one-half of the cases 

 immunized intraperitoneally were proof against a subdural infection. 



The treatment of tetanus by antitetanic serum, E. E. Irons {Jour. Infect. 

 Diseases, 15 {191Jf), No. 2, pp. 367-377). — An analysis of 225 cases treated 

 during the period 1907 to 1913 shows the mortality of tetanus treated by tetanus 

 antitoxin to be about 20 per cent lower than the average mortality of tetanus 

 treated without serum. The mortality of the cases treated by efficient methods 

 and adequate doses is considerably lower than that of cases receiving small doses 

 subcutaueously. 



On the American method of standardizing tetanus antitoxin, A. MacConkey 

 {Jour. Hijg. [Cambridge], 13 {WW, No. 4, pp. 467-492) .—This is a study of the 

 American method (E. S. R., 20, p. 379) of standardizing tetanus antitoxin. 

 In the exiieriments two standard toxins were examined. It was found " that, 

 provided control experiments are carried out from time to time (as in the case 

 of standard diphtheria toxin), this method of standardizing tetanus antitoxin 

 is — as claimed for it — simple, accurate, and reliable." 



Gosio's vital reaction for the tubercle bacillus, S. Belfanti {Ztschr. 

 Chemother., I, Orig., 1 {1912), No. 2, pp. 113-121, figs. 2; ahs. in Zentbl. Biochem. 

 11. Biophys., 14 {1913), No. 22, p. 87S). — Living tubercle bacilli of the human, 

 bovine, and avian types sti'ongly reduce potassium tellurate. The intensity 

 of the reaction is proportional to the vitality of the organisms. In addition 

 to the reducing properties, the tubercle bacillus possesses synthesizing powers 

 toward tellurium salts. Compounds are produced which possess a garlic- 

 like odor. 



Precipitating action of blood serum with lipoids of the tubercle bacillus, 

 L. Pbeti {MUnchen. Med. Wchnsehr., 61 {1914), ^0. 5, p. 241). — It was observed 

 that when an emulsion of the lipoidlike substances obtained by extraction of 

 1 to 2 months' old tubercle bacilli with alcohol and ether was added to the 

 blood serum of patients affected with tuberculosis, a marked precipitate was 



