542 



SUBJECT INDEX 



Gene for beta-galactosidase, 281 

 Gene mutations, 212-214 

 Glueosyl transferases, 57-58 

 Glucosj'lation of 5-hydroxymetliylcyto- 



sine, 56-59 

 Gradient centrifugation, 



cell components, 273-274, 316-321 



DNA, 77-80 



H 



Half-chromatids, 67, 99 

 Hcmoglobin-A2, 418-419 

 Hemoglobin-A3, 420-421 

 Hemoglobin-F, 415, 418, 421 

 Hemoglobins, 405-469 

 abnormal, 421-434 

 amino acid substitution in variants, 



42&-434 

 control mechanism in sj'nthesis, 456- 



461 

 dissociation and recombination, 440- 



442 

 genetics of, 436-438, 444-447, 462-465 

 mode of assembly of molecule, 439-440 

 sequence of amino acids in the chains, 



419-420 

 structure of, 409-415 

 Homopolymers, 54 



of DNA, 54 

 Hj'drazine, reaction with DNA, 227 

 Hydrogen bonds in DNA, 81 

 Hydrogen ion concentration (pH), 



mutagenic effect, 230 

 Hydroxylaminc, mutagenic effect of, 227- 

 230 

 reaction with bases of DNA, 227-228 

 with bromouracil, 229 

 with cytosine, 228-229 

 5-Hydroxymethyldeoxycytidylic acifl, 10- 

 12 

 synthesis of, 10-12 

 Hypochromicity as a test for DNA syn- 

 thesis, 19 



K 



Kinase, deoxycytidylate, 15 

 Kinases, 12-17 



dGMP, 16 



deoxj'nucleoside diphosphate, 15-17 



thymidylale, in bacteria and HeLa 

 cells, 173-174 

 in liver, 171-172 



Linkers, chromosome, 98, 108 



M 



Maps, genetic, 

 E. coli, 146 

 mutations, 248-249 

 T-even phages, 131-135, 212 

 in rll region, 213 

 Messenger RNA, see RNA 

 Microsomes, 292 

 Mitotic cycle, 155-156 



measurement of length, 156-157 

 Mitosis, synchronization, 181 

 Mutagenic specificit}^ and the reaction 



of certain bases, 254 

 Mutagens, 217-218 

 specificity of, 252 

 Mutations, 207-264 

 classification of, 20&-209 

 forward, specificity of, 252 

 induction, in TMV, 497-499 



kinetics of, 250 

 phages for stud}' of, 211-215 

 reverse, 249 



specificity of, 253 

 spontaneous, 245-248, 263-264 

 suppressor, 254 



N 



Nitrogen-15 and DNA labeling, 78-79 

 Nitrogen mustard, see Alkylating agents 

 Nitrous acid, mutagenic effect of, 225-227 

 Nucleosides in relation to mitotic cycle, 

 159 



Peptide bond 



formation of, 374-378 

 Peptide chain 



formation of, 373-374 

 Phage, see Bacteriophage 

 Phosphodiesterase, 23-24, 54 

 Phosphorus-32 as label for DNA, 18 



