Organization and Replication of DNA in Vivo 277 



REFERENCES 



Bendich, A., and Rosencranz, H. S., "Some Thoughts on the Double-Stranded Model of 

 Deoxyribonucleic Acid," Progr. Nucleic Acid Res., 1 :219-230, 1963. 



Crick, F. H. C, "Nucleic Acids," Scient. Amer., 197:188-200. 1957. 



Jehle, H. n Ingerman, M. L., Shirven, R. M., Parke, W. C, and Salyers, A. A., "Replica- 

 tion of Nucleic Acids," Proc. Nat. Acad. Sci., U.S., 50:738-746, 1963. 



Luzzati, V., "The Structure of DNA as Determined by X-ray Scattering Techniques," 

 Progr. Nucleic Acid Res., 1:347-368, 1963. 



Meselson, M., and Stahl, F. W., "The Replication of DNA in Escherichia coli," Proc. 

 Nat. Acad. Sci., U.S., 44:671-682, 1958. 



Peacock, W. J., "Chromosome Duplication and Structure as Determined by Auto- 

 radiography," Proc. Nat. Acad. Sci., U.S., 49:793-801, 1963. 



Rapoport, I. A., and Kostyanovskii, R. G., "The Mutagenic Activity of Several Inhibitors 

 of Cholinesterase," Doklady Akad. Nauk SSSR, 131:191-194, 1959 (in Russian). 



Ris, H., and Chandler, B. L., "The Ultrastructure of Genetic Systems in Prokaryotes 

 and Eukaryotes," Cold Spring Harb. Sympos. Quant. Biol., 28:1-8, 1964. 



Sueoka, N., "Mitotic Replication of Deoxyribonucleic Acid in Chlamydomonas rein- 

 hardi," Proc. Nat. Acad. Sci., U.S., 46:83-90, 1960. 



Watson, J. D., and Crick, F. H. C, "Molecular Structure of Nucleic Acids. A Structure 

 for Deoxyribose Nucleic Acid," Nature, London, 171:737-738, 1953a. Reprinted 

 in Classic Papers in Genetics, Peters, J. A. (Ed.), Englewood Cliffs, N.J.: Prentice- 

 Hall, 1959, pp. 241-243. 



Watson, J. D., and Crick, F. H. C, "Genetical Implications of the Structure of Deoxy- 

 ribonucleic Acid," Nature, London, 171:964-969, 1953b. Reprinted in Papers on 

 Bacterial Genetics, Adelberg, E. A. (Ed.), Boston: Little, Brown, 1960, pp. 125- 

 130. 



Watson, J. D., and Crick, F. H. C, "The Structure of DNA," Cold Spring Harb. 

 Sympos. Quant. Biol., 18:123-131, 1953c. Reprinted in Papers on Bacterial 

 Viruses, Stent, G. S. (Ed.), Boston: Little, Brown, 1960, pp. 193-208. 



See bibliography and all but last portion of Supplement IV. 



QUESTIONS FOR DISCUSSION 



20.1. Can you draw any conclusions from the observation that most of the multi- 

 cellular organisms studied are richer in A + T than C -f- G? 



20.2. Among the DNA molecules contained in a genome, why is it expected that 

 many would differ in base sequence and content? 



20.3. How many different base pairs normally occur in a double helix of DNA? 

 What are they? 



20.4. If a coil is right-handed when looked at from one end, is it also right-handed 

 when seen from the other end? 



20.5. What would you have expected to see in the ultracentrifuge tube following sonic 

 treatment of DNA or following the conversion of DNA to its single-stranded 

 condition, if synthesis had occurred at the ends of the double DNA helix? 



20.6. What evidence can you give that heating double-helix DNA causes the strands 

 to separate? 



