Transduction 337 



SUMMARY AND CONCLUSIONS 



Genetic recombination of loci of the bacterial chromosome can be mediated by tem- 

 perate bacteriophages in the process of genetic transduction. 



The transduced segment can be derived from any region of the bacterial chromosome 

 (as in generalized or unrestricted transduction) or from a narrowly limited region (as 

 in specialized or restricted transduction). The DNA segment transduced may, by 

 integration, replace a chromosomal marker of the host (as in complete transduction), 

 or it may produce a merozygote, in which case the exogenote can still function, whether 

 it can replicate (as Gal exogenotes in E. coli) or not (as the exogenote in abortive 

 transduction in Salmonella). 



A transducing <£ lambda is defective in its own genome. The deficient portion is 

 replaced by a small segment of bacterial DNA acquired at the time the prophage was 

 induced in its last host. 



Most temperate phages are episomes which, when attached to the chromosome, have 

 some characteristics resembling those of integrated F. 



Norton D. Zinder. about 1954. 



REFERENCES 



Arber, W., Kellenberger, G., and Weigle, J., "The Defectiveness of Lambda-Transduc- 

 ing Phage" (in French), Schweiz. Zeitschr. Allgemeine Path, und Bact., 20:659- 

 665, 1957. Translated and reprinted in Papers on Bacterial Genetics, Adelberg, 

 E. A. (Ed.), Boston: Little, Brown, 1960, pp. 224-229. 



Campbell, A., "Transduction," pp. 49-89, in The Bacteria, Vol. 5, Heredity, Gunsalus, 

 I. C., and Stanier, R. Y. (Eds.), New York: Academic Press, 1964. 



Jacob, F., and Wollman, E. L., "Spontaneous Induction of the Development of Bac- 

 teriophage A in Genetic Recombination of Escherichia Coli K 12" (in French). 

 C. R. Acad. Sci. (Paris), 239:317-319, 1954. Translated and reprinted in Papers 

 on Bacterial Viruses, Stent, G. S. (Ed.), Boston: Little, Brown, 1960, pp. 336-338. 



Jacob, F., and Wollman, E. L., "Genetic Aspects of Lysogeny," pp. 468-500, in A 

 Symposium on the Chemical Basis of Heredity, McElroy, W. D., and Glass, B. 

 (Eds.), Baltimore: The Johns Hopkins Press, 1957. 



