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a. No reader who recognizes deoxyribonucleic 

 acid will need to be reminded what DNA stands 

 for. 



b. One might be tempted to write: "One DNA 

 molecule = one gene." However, the quanta of 

 factorial genetics, based on mutation, recombina- 

 tion, and enzymatic function are all smaller than 

 the DNA unit of molecular weight — 6 X i° 6 

 (4). There is increasing evidence that such a 

 molecule is a natural unit rather than an artefact 

 of fragmentation. 



c The experimental work from my laboratory 

 summarized in this paper has been generously 

 supported by research grants from the National 

 Institutes of Health, U.S. Public Health Service, 

 the National Science Foundation, the Rockefeller 

 Foundation, the Wisconsin Alumni Research 

 Foundation, the University of Wisconsin, and, 

 most recently, Stanford University. It is also a 

 pleasure to record my thanks to the Jane Coffin 

 Childs Fund for Medical Research for a research 

 fellowship which supported my first association 

 with Professor E. L. Tatum. 



s-110 



