Subjects 



551 



measles, 78, 389 



medulla. 107 



megasporocvte and megaspores, 



25, 26' 

 meiosis, 15-23. 156. 157 



and gene pairs, 47, 48 



in Neurospora, 124, 125, 126 

 meiotic drive, 388 

 Melandrium, 115 

 Melanoplus. 493 

 melanotic tumors and episomes, 



370 

 merogenote, 320 

 meromixis and merozygote, 320 

 messenger RNA (mRNA), 425- 



431, 430 (see also RNA) 

 metagon, 454. 5 1 3 

 metamorphosis. 24 

 metaphase, 8, 9, 17, 18, 20, 21 

 methyl green stain, 261 

 methylation, DNA and RNA, 



429 

 micronucleus, 374 

 microspectrophotometry, 261 

 microspores and microsporocytes, 



25 

 migration, 203, 242 

 mistakes, incorporation and rep- 

 lication, 398 

 mitochondria, 7, 377, 378, 505, 



513 

 mitomycin C, 396 

 mitosis, 5, 6, 8, 9, 10 



radiation effect on, 184-185 



regulation of. 503 

 mitotic rate and mutations, 222, 



383 

 Modulator, 466-469 

 molecular evolution of hemo- 

 globin, 418-419 

 mollusc chromosome, 496 

 monad, 16 

 monoecious, 25 

 monohybrid, 45 

 monomers, 280 

 monosomic. 107-108, 156 

 moon, 515 



morphological barriers, 245 

 mosaicism, 106-108, 106, 161, 

 370-373, 371, 474 



erythrocyte, 504 



functional, 485 

 mosquito, 246 

 mosses, 1 1 1 

 moths, 95, 107 



mottled vs. sectored plaques, 344 

 mouse, 69, 83, 84, 88, 107-110, 

 1 14, 479, 502 



aneusomy, 160 



crossover map, 140-141 



heart mitochondria, 377 



position effect in. 486-487 



tissue culture. 503 

 multigenic (polygenic) traits, 



62-65 

 muscular dystrophy. 485 

 mutagens and antimutagens, 192, 



225. 391-392 

 mutant, 5 (see also gene; muta- 

 tion) 



bacterial, isolation of, 294 



constitutive, 459 



detection of. 149-151, 195-198 



detrimental nature. 193-194 



lethal (see lethals) 



in natural populations, 216, 217 



pre- or postadaptive, 306-309 



sub- and supervital, 216, 217 



suppressor, 437-440 



temperature sensitive, 501 



visible, 198 

 mutation (see also mutant), 5 



in bacteria, 306-309 



defined operationally, 399-400 



and evolution, 220-221 



frequency, 192, 204 



gene, 190 



genetic control of, 383-389 



germinal, 222-225 



intergenic, 191 



molecular basis of, 391-400 



point. 189-198, 345, 392-399 



and populations. 202 



repair from, 397 



rate, 192, 193, 224-225, 309, 

 392 



reverse, 393, 468 



somatic, 221-222 



at specific loci, 192 



spontaneous, 179, 192, 224 



sub-nucleotide, 394-399 



time of. 193 



and ultraviolet, 396-397 



whole nucleotide, 393-394 

 mutational damage, 221-225 

 mutational "hot spots." 392 

 mutational spectra, 192, 392-393 

 mycelium, 26 

 Mycobacterium, 452 

 myoglobin, 418-419 



natural selection, 202-205, 245, 



513 

 nearest-neighbor analysis, 286- 



288, 397 

 Neisseria, 297 

 neomorph, 194 

 neurons and RNA, 505 

 Neurospora (bread mold), 26. 

 27, 124, 125, 126. 408-410 

 bibliography. 29 

 crossover map, 144 

 mitochondria. 377, 378 



newt, 493, 495 

 Nicotiana (tobacco), 60-62 

 nitrous acid as mutagen. 396 

 nondisjunction, 95-98, 159, 384, 



475-476 

 nonlysogenic (sensitive) strain. 



331 

 normal curve. 534 

 nuclear body in E. coli, 293 

 nuclear membrane, 6, 7 

 nuclear transplantation. 502 

 nucleic acid, 253 



as genetic material (see genetic 

 material; DNA; RNA) 



hybrid, 425 



methylated, 429 



subservient role of, 512 

 nucleolus. 6, 7, 427, 493, 495, 

 496 



organizer. 11, 427 

 nucleoplasm, 6 

 nucleoprotein. 263, 496-498 

 nucleoside, 257, 258, 263 



phosphate kinases, 450 

 nucleotide, 257, 263 



sequence in TMV, 366 

 nucleus, 6, 7, 9, 25, 26 

 null hypothesis, 526 

 nullosomic, 159 

 nurse cells. 24, 492, 494 



octoploid, 151 

 ocular albinism, 490 

 Oenothera (evening primrose), 



151, 228-236. 228, 481 

 oligonucleotide, 287 

 ommatidia, 474, 476 

 one gene one enzyme, 408-410 

 one gene one polypeptide, 410- 



418 

 one gene one primary effect, 407- 



408 

 onion, 9, 496 



oocyte, 24, 160, 223, 493-496 

 oogenesis, 24 

 oogonia, 24 

 operons, 457-462, 469-470, 489 



514 

 Ophryotrocha, 1 1 1 

 organic bases, 253-256 

 origin (O). point of. 320 

 ovaries and ovarioles, 24 

 oxidase, homogentisic, 406 

 oxygen and mutation. 182 

 ozone. 5 1 1 



P,. P L „ 32 



pachynema. 16, 17, 19, 173 

 panmixis, 205 

 paracentric. 166, 167 

 parahydroxylase, 407 



