682 EXPERIMENT STATION RECORD. 



normal guinea pigs an intoxication resembling, if not identical with, the 

 specific immediate protein intoxication in hypersensitive pigs. The gross path- 

 ological findings appear to be similar in both conditions. The minimum fatal 

 dose of 2 preparations was 1 part to 15,000 parts of body weight. Boiling for 

 1 minute with filtration does not affect the potency of the watery solution. 



" Fatal doses of the poison cause an abrupt fall in temperature. Smaller 

 amounts (up to 0.01 gm. for pigs from 200 to 250 gm.) are apparently without 

 appreciable effect on the body temperature. Under the experimental conditions 

 noted, repeated increasing doses of poison fail to render animals immune to 

 a minimum fatal dose. Survival from a large intravenous dose of the poison 

 apparently renders the animal refractory, for 48 hours at least, to an amount 

 in excess of that required to kill. Fresh brain, lung, and liver tissue, under 

 the conditions noted, showed no binding or neutralizing affinity for the poison. 

 Normal guinea pig serum has little if any destructive action on the cell poison. 

 Intradermic injections of 0.00005 gm. of the poison produced no local reactions 

 in normal or sensitized pigs. 



"Atropin sulphate protected 75 per cent of the animals from a sjTichronous 

 injection of fatal amounts of poison. Morphin sulphate aborts the acute 

 sympoms and delays death, and in 2 cases completely protected from fatal 

 intoxication. Chloral hs^drate protected many of the animals against an other- 

 wise fatal dose of the poison, and inhibited the acute manifestations and delayed 

 death in others. Lecithin emulsion injected simultaneously with the poison 

 seems to possess a slight and irregular prophylactic action. Incubation of the 

 poison with lecithin emulsion for 1 hour at 27.5° C. increases this neutralizing 

 property. A dose of 1 : 12,000 of the poison was not affected. The preliminary 

 administration of lecithin protected some of the animals, delayed death In 

 others, and was without effect in the remainder. The results were too incon- 

 stant to warrant definite conclusions." 



A bibliography embracing 17 titles is included. 



Protective vaccination against tuberculosis with killed tubercle bacilli 

 contained in reed sacks, G. Heymans (Deut. Med. Wchnschr., 38 (1912), No. 

 23, pp. 1081, 1082; ahs. in Ztschr. Immunitatfif. n. E.rpt. Ther., II, Ref., 5 (1912), 

 No. 13, p. 317). — Living tubercle bacilli when contained in these sacks migrate 

 through the capillaries of the vegetable vascular tissues (bacterial ultradia- 

 pedesis). By treating the reed sacks with collodion this migration can be 

 stimulated or inhibited. 



Tubercle bacilli killed with alcohol are well borne up to 1 gm. of substance 

 by sound or tubercular animals. In some instances immunizing properties 

 (protective and curative) were noted. 



The treatment of tuberculosis with paratoxin, G. Lemoine (Rev. Mod. M6d. 

 €t Chirurg., 10 (1912), No. 1, pp. 6-11; abs. in Internet. Ccntbl. Gesam. Tuber- 

 kiilose Forsch., 6 (1912), No. 7, pp. 365, 366).— Paratoxin is an extract of the 

 gall and contains liix)id-like substances which possess an antibacillary power. 

 They probably exert their power in conjunction with the phagocytes. Several 

 thousand patient^, treated with this preparation showed a decrease in bacterial 

 toxemia, which was probably due to a diminution of the number of bacteria in 

 the body. 



Tuberculosis in cattle (Brit. Med. Jour., 1912, No. 2692, pp. 263, 264).— A 

 statistical and general discussion by Del^pine and Wilson in regard to the occur- 

 rence of tuberculosis in Germany. France, Great Britain, and Denmark at a 

 conference of the veterinary association held at Melbourne. 



The agglutination test in the diagnosis of bovine contagious abortion, 

 J. McFadykan and S. Stockman (Jour. Compar. Path, and Ther., 25 (1912), 



