282 EXPERIMENT STATION EECORD. 



"The resistancp of cattle can be overcome and iiifeciion hnmslit about l)y 

 inoculation of liunian bacilli in larse nunil)ers or in moderate numbers if the 

 inoculations are leapt up for a prolonged period of time. 



" Human beings are sometimes infected with bacilli of bovine type. 



" Reasoning from the data obtained from the diagnostic and therapeutic use 

 of tuberculins made from bacilli of bovine and human types, we conclude that: 



" Bovine and human bacilli are different in that their toxins are different. 



" Judging from tlie maimer in which patients suffering from tuberculosis 

 react toward tuberculins made from human and l)ovine bacilli, we would con- 

 clude that both varieties of bacilli are able to produce tuberculosis in the 

 human body, but that the localization of the two infections is more or less con- 

 stant. We have found that : 



" A, Infections of the lungs, larynx, and intestines, when complicating tuber- 

 culosis of the lungs, are, as a rule, best treated by tuberculins made from 

 bovine bacilli. These infections are most probably produced by l)acilli of 

 human origin. 



" B. Infections of the bones, glands (as a rule), ]»eritoneum (with effusion), 

 ear and genito-urinary tract are, as a rule, best treated liy tuberculins made 

 from human bacilli. These infections are most itrobably produced liy bacilli 

 of bovine origin, 



"Reasoning from the analogy furnished by smallpox, the fact that human 

 bacilli will immunize cattle against infection with bovine bacilli would suggest 

 that bovine bacilli might immunize human beings against human bacilli ; and, if 

 our belief that tuberculosis of the bones is of bovine origin is true, and our 

 observation that persons suffering from bone lesions rarely suffer from tubercu- 

 losis of the lungs is correct, we have clinical evidence whicli supports the fact 

 that immunity in human beings against human bacilli may be produced by 

 infection with bacilli of the bovine type.'' 



Tuberculosis among animals, W. A. Breno (Sci. Prog. Twentieth Cent., 3 

 {1D08), \o. it, pi>. IJS-'A)). — This is a brief review of recent work as related to 

 the differences in the degree of susceptibility to tuberculosis exhibited by 

 different classes of animals. 



The economic importance of tuberculosis of food-producing animals, A. D. 

 Melvin {Amer. Yet. Rev., 35 {1909), A'o. 1, pp. lS-32). — An address pi-esented 

 before the International Congress on Tuberculosis, held at Washington, D. O., 

 in 1908, in which the subject is discussed at length. 



It is concluded, as a general average, that about 3.5 per cent of the cattle of 

 the United States are affected with tuberculosis. The loss on all food animals 

 killed in this country is estimated at $3,832,436 annually. " Taking into con- 

 sideration the various items mentioned, the tribute which the United States 

 pays each year to this scourge among its farm animals aggregates more than 

 $14,000,000. Such a loss is too great, merely as a matter of economics, to be 

 allowed to continue and increase from year to year." 



The curative treatment of tuberculosis in cattle by Professor von Behring's 

 tulaselaktin (Ahs. in Jour. Compar. Path, and Then, 22 (1909), No. 1, pp. S.'/- 

 96). — This is an extract from the official report presented by the commission 

 to the minister of agriculture of Argentina. The facts recorded in this report 

 lead the commission to the following conclusions : 



" Prof, von Behring's tulaselaktin has had no prejudicial effect on the experi- 

 mental cattle, for the local reaction (at the seat of the injections) observed in 

 some of the animals, and the general reaction, due to pulmonary congestion 

 (very similar to that sometimes produced by an injection of tuberculin), noted 

 in others, were temporary and apparently without influence on the subsequent 

 development uf the lesions. 



