VETEKINARY MEDICINE. 681 



no influence upon the fatal outcome of anaphylaxis. Further work upon the 

 specificity of anaphylaxis emphasizes the specific nature of this phenomenon. 

 The effect of heat in modifying or destroying the sensitizing or poisonous prop- 

 ertes of proteins probably depends entirely upon its effect in rendering the 

 proteins insoluble, rather than by the production of chemical changes in the 

 protein. . . . 



" There is apparently no difference in the subsequent immunity whether the 

 intoxicating injection be given subcutaneously, intraperitoneally, or intracrani- 

 ally. In these cases the immunity was tested 24 hours after the second injec- 

 tion. We present preliminary evidence suggesting that antibodies are con- 

 cerned in the mechanism of anaphylaxis. The mixture of normal horse serum 

 with the blood serum of a sensitive guinea pig apparently increases the toxicity 

 of the horse serum for sensitive guinea pigs. We have shown that guinea pigs 

 may remain sensitive 1,09G days; that is, a little over 3 years." See a pi'e- 

 vious note (E. S, R., 20, p. 1183). 



On the intestinal resorption of serum antitoxin and milk antitoxin, P. H. 

 RoMEE {Ztschr. Immunitatsf. u. E.rpt. Tlier., I, Orig., 1 {J 909), No. 2, pp. 171- 

 192; abs. in Milchiv. ZentU., 5 {1909), No. 8, p. 375). — The author's experiments 

 indicate that the intestinal canal has a greater power to resorb milk antitoxin 

 than a homologous serum antitoxin. These results confirm those obtained by 

 Bertarelli (E. 8. R.. IT, p. 001). 



Form and size of red blood corpuscles in domestic animals, E. Retterer 

 iVoiiipt. Rciid. Soc. Biol. [Puris], 65 {190S), No. 36, pp. 59-J-o.O 6). —The author 

 finds that the red blood corpuscles of the ox, sheep, goat, pig, and horse are 

 solid. Most are spherical, others hemispherical and lenticulai*. 



Oleander poisoning of live stock, F. W. Wilson (Arizona Sta. Bui. 59, pp. 

 3S1~397, figs. 6). — The literature showing that the oleander (Neriiim oleander) 

 is poisonous when eaten by human beings, rodents, and common farm animals 

 is reviewed and experimental data reported. 



Three active principles, all of which are glucosids, have been found in the 

 oleander, of which the most important is oleandriu. The oleander occurs native 

 in the Mediterranean regions of the old world, also in Persia, Japan, and the 

 East Indies, whence it has been distributed to most warm countries. It grows 

 readily in the open throughout the southern part of the United States and is 

 much used as a house plant in many northern and eastern homes. Both the 

 white and pinlv varieties were used in the investigations reported, but little 

 difference in their poisonous action being found. The details in regard to 

 dose, symptoms, and post-mortem appearance in experiments with 2 horses, a 

 cow, a mule, and 3 sheep are reported. 



" The amount of oleander necessary to cause death in horses ranges from 

 15 to 20 gm. of green leaves, and from 15 to 30 gm. of dry leaves. This depends 

 on the condition of the animal at the time the poison is obtained. A full 

 stomach will necessitate more poison. In the case of cows it is safe to say 

 that from 10 to 20 gm. of green leaves and 15 to 25 gm. of dry leaves are suf- 

 ficient to cause death. For sheep the fatal dose of either green or dry leaves 

 is from 1 to 5 gm. There is little danger in the bark, roots, or flowers since 

 live stock would hardly obtain sufficient poison in that way. . . . 



" The general symptoms are increased temperature and pulse, coldness of the 

 extremities, warm body temperature, dilation of the pupils of the eyes, and 

 discoloration of the mouth and nostrils, followed by sore mouth. The body 

 becomes wet with sweat, due to the exertion caused by the powerful heart 

 stimulation. The animal generally refuses to eat or drink during the 24 hours 

 preceding death. This is usually due to soreness of the mouth and throat, 



