1917] VETERINARY MEDICINE. 279 



albumin-free tuberculin, iodotuberculin, and compounds prepared from copper 

 salts and cyanids, designated as liquids A, B, C, and D, are reported. 



The effect of a single injection of these liquids upon the tuberculous lesions 

 was found to be either negative or inconspicuous. After repeated injections, 

 however, the congestion and leucocytic infiltration about the lesions decreased 

 markedly, the cheesy material resulting from degeneration of the lesions and 

 other degeneration products appeared to be in a process of absorption, and 

 young connective tissue was being actively produced in the periphery. 



While these changes were taking place the number of the bacilli was also 

 being reduced until finally tliey could no longer be detected on microscopical 

 examination. " Hence it appears that while the preparation may lack bac- 

 tericidal action in vivo powerful enough to destroy all the bacilli at one injec- 

 tion, yet repeated infusions may nevertheless bring about the destruction of 

 all the bacilli and the modification of the tubercular lesion into that of the 

 suspended stage or even into the healed condition. Whether, therefore, the 

 preparation brings about these results directly by killing the bacilli or indi- 

 rectly by favoring the healing processes of the body, nevertheless it has power 

 to inhibit the growth of or annihilate entirely the bacilli in vivo." 



So far as microscopic examination was concerned sterility of the tissues 

 was obtained. Emulsions of the various organs of treated animals injected 

 into healthy animals did not, however, yield consistent results, so that abso- 

 lute sterility in all animals was not obtained. 



A contribution to the chemotherapy of tuberculosis. — First clinical report, 

 G. KoGA {Jour. Expt. Med., 24 {1916), No. 2, pp. U9-186, pis. 6, figs. 20).— A 

 number of eases are reported in detail which indicate that the preparation 

 " liquid D," noted above and designated as " cyanocuprol," " greatly improves 

 or apparently cures pulmonary and surgical tuberculosis in the first and second 

 stages, and that it seems also to produce beneficial effects upon the disease in 

 the third stage." 



It is indicated that the duration of the beneficial effects must be established 

 more definitely by further observations. 



The etiology of bovine metritis, B. Eggink {Aetiologie der Metritis beim 

 Rinde. Inaug. Diss., Univ. Bern, 1914, pp. 75). — The author briefly reviews the 

 classification of uterine diseases as arranged by earlier investigators, and dis- 

 cusses the general considerations in regard to endometritis, puerperal infec- 

 tion and intoxication, etc. The etiology of uterine infections, bacteria found 

 in the bovine genitals, investigation of a number of cases of metritis, the relation 

 between metritis and post-partum polyarthritis, and the serum treatment of 

 uterine diseases are also discussed. 



It is concluded that the previously accepted classification of the various forms 

 of metritis is a purely clinical one. Considered from the etiological standpoint 

 there is really no difference between the various forms. They are considered 

 to be caused by the same micro-organisms, and under the term metritis every 

 infection of the uterus (plus its contents) should be Included. There ai'e 

 always a greater or lesser number of virulent organisms present in the uterus 

 which exercise their pathogenic influence either by local action on the tissues, 

 by the production of a general toxemia, or by a combination of both. Post- 

 partum polyarthritis is considered always to be secondary and the result of 

 an earlier uterine infection by specific organisms. 



Serum treatment in metritis, especially the injection of Streptococcus 

 pyogenes antiserum as a prophylactic after difficult parturition and also as a 

 curative agent in active infections, is recommended. 



A bibliography of 69 references is included. 



