382 EXPEEIMEIsTT STATION RECORD. [Vol, 36 



cent). In animals that presented no positive clinical evidences of the disease 

 35 per cent of the reactions were positive. The previous history of these ani- 

 mals, however, was unknown. 



It is indicated that, while the " skin test may prove of practical value in the 

 diagnosis of canine distemper and particularly as an index of a previous in- 

 fection in an apparently normal animal, it is probable that it has no value as 

 an index of immunity and that an animal presenting a positive reaction is still 

 susceptible to relapses or recurrences of the disease." 



Anaphylactic skin reactions in relation to immunity.— IV, The relation 

 of the bronchisepticin skin reaction to immunity in canine distemper in- 

 cluding- the bactericidal action of dog serum for Bacillus bronchisepticus, 

 J. A. KoLMEB, T. Matsunami, and M. J. Harkins {Jour. Immunol., 1 (1916), 

 No. 5, pp. 571-5SJt). — Further anaphylactic skin tests indicate that a large per- 

 centage of dogs are hypersensitive to the protein of B. bronchisepticus and 

 that the reactions are probably specific. 



The sera of normal animals, those suffering with the disease, and those con- 

 valescent from the infection were found to possess very little or no bactericidal 

 activity over the micro-organism as measured by tests in vitro. It is indicated 

 that dogs yielding positive bronchisepticin reactions are still susceptible to caniue 

 distemper. 



A contribution to the study of the chang-es in the blood count in dourine, 

 N. PoPESco {Abs. in Jour. Amer. Vet. Med. Assoc, 48 (.1916), No. 4, PP- 4^9, 

 470). — A report of studies made while in search of a method of early diagnosis. 



The virulence of the blood of animals affected with, foot-and-mouth dis- 

 ease, G. Cosco and A. Aguzzi {PoUclin., Sez. Prat., 23 (1916), No. 18, pp. 551, 

 552; abs. in Jotir. Amer. Med. Assoc, 66 (1916), No. 24, p. i895)..— During the 

 course of investigations made under the auspices of the National Public Health 

 Service of Italy the blood of 116 cattle was found virulent during the entire 

 febrile course of the disease, as virulent as the contents of the vesicles. The 

 red corpuscles and the serum seem to be equally virulent and the defibrinated 

 blood kept on ice retained its virulence for over a month. Erythrocytes thor- 

 oughly rinsed from all traces of serum, and the serum alone, reproduced the 

 diseases on subcutaneous injection of other cattle with a dose as small as 1 cc. 

 The authors consider the erythrocytes to be ideally adapted for the production 

 of vaccine and are working along this line. 



The K. H. reaction in glanders, J. Kbanich and W. Kliem (Ztschr. Ve- 

 terinark., 27 (1915), No. 10, pp. 289-296).— A modified technique for the K. H. 

 reaction of Pfeiler and Scheyer (E. S. R., 34, p. 276), which consists of com- 

 plement deviation and hemagglutination, is described in detail. The system 

 used is composed of horse serum as complement, bovine serum as amboceptor, 

 guinea pig corpuscles as hemolytic antigen, the glanders bacillus, and the serum 

 to be examined. 



The procedure is deemed to yield excellent results and is highly recom- 

 mended. The name hemagglutination reaction is proposed in place of K. H. 

 reaction. 



Johne's disease, J. M'Fadyean and A. L. Sheathee (Jour. Compar. Path, 

 and Ther., 29 (1916), No. 1, pp. 62-94)- — Reports are given upon the experi- 

 mental transmission of the disease to cattle, sheep, and goats, with notes 

 regarding the occurrence of natural cases in sheep and goats. The facts here 

 recorded suggest that among sheep the disease may have a wider distribution 

 than has heretofore been suspected. 



Milk in relation to Mediterranean fever, C. PoacHER and P. Godard (Le 

 Lait et la Fidvre M^diterran^enne. Paris: AsseUn d Houseau, 1916, pp. II4, 

 pis. 4, fiffs. S). — This is a contribution to the study of the role which milk plays 



