1917] VETERINAKY MEDICIITE. 479 



It is indicated that cattle harboring warble larvae become sensitized to 

 them, and that when the system becomes suddenly flooded with the protein 

 of the larvae (and possibly toxins) anaphylactic shock results. 



The effect of toluene on the production of antibodies, L. Hektoen {Jour. 

 Infect. Diseases, 19 (1916), No. 6, pp. 737-745). — Similar experiments to those 

 made with benzene, previously noted (E. S. R., 35, p. 781), were made with 

 toluene, and the results reported. 



In repeated doses of about 1 cc. per kilogram of body weight the toluene 

 diminished the output of antibody in the earlier periods of antibody protluc- 

 tion, and under certain conditions caused long persistence of antibody in the 

 blood, with marketl fluctuations in the concentration in some of the cases. The 

 same increased persistence of antibody in the blood may result from the injec- 

 tion of smaller doses of toluene. 



No immediate change as to number and proportion of leucocytes in the blood 

 of rabbits nor any change in the phagocytic activity of the leucocytes in vitro 

 was observed. 



" In rabbits receiving the larger doses of toluene there occurs a transitory 

 myeloid hyperplasia in the bone marrow, but later no marked changes in the 

 marrow or other organs appear. On this account there is at present no basis 

 for concluding whether the fluctuation and persistence of antibodies in the 

 blood is better explained as resulting from increased and prolonged production 

 of antibodies, or as resulting from interferences with the passage of anti- 

 bodies out of the blood." 



Comparative action of antiseptics on pus and on pure cultures, A. Lumi^ke 

 (Conipt. Rend. Acad. »SVi. [Paris], 163 {1916), No. 13, pp. 309-311).— Data are 

 submitted which show the marked effect of the albuminous material of pus in 

 decreasing the bactericidal action of phenol, hermopheuyl (mercuric phenol 

 disodium sulphonate), and sodium hypochlorite. 



For the treatment of suppurating wounds the free use of relatively con- 

 centrated hypochlorite solutions is recommended. It is indicated that the 

 hypochlorite oxidizes the toxins of the pus and plays an important part in the 

 defense of the organism against intoxication and the spread of infection. 



The significance of certain natural flag'ellates of insects in the evolution 

 of disease in vertebrates, H. B. Fantham and Annie Poetek {Jour. Parasi- 

 tology, 2 {1916), No. 4, pp. U9-166, figs. 2).— A further report of work (E. S. R., 

 35, p. 782). 



Observations on the blood in East Coast fever of cattle, C. Strickland 

 {Parasitology, S {1916), No. 3, pp. 2U-248) .—" There is very little, if any, 

 abnormal destruction of erythrocytes in cases of infection with East Coast 

 fever. This is proved by blood counts, hemoglobin estimations, and the condi- 

 tion of the blood-forming and blood-destroying organs, all remaining practically 

 normal. This is in marked contrast to what obtains in piroplasmosis. 



" The hypothesis advanced by Nuttall fits all the facts. According to this 

 hypothesis the invasion of the corpuscles occurs in the internal organs where 

 the parasites develop, and the corpuscles only act as carriers of the parasites in 

 the blood, thereby conveying them to the tick which serves as the vector. Since 

 few, if any, of the corpuscles are destroyed they rapidly become charged with 

 an increasing number of parasites, which are being continuously produced in 

 the internal organs as evidenced by Koch's blue bodies which form and break 

 up in the lymphatic glands, spleen, liver, bone marrow, etc. (Gonder, Nuttall). 



" There is a marked leucopenia in East Coast fever, the polymorphs decreas- 

 ing less rapidly than the other elements. This is in contrast with the leuco- 

 cytosis observable in piroplasmosis." 



